Login / Signup

DNA methylation networks underlying mammalian traits.

Amin HaghaniCaesar Z LiTodd R RobeckJoshua ZhangAke T LuJulia AblaevaVictoria América Acosta-RodríguezDanielle M AdamsAbdulaziz N AlagailiJavier AlmuniaAjoy AloysiusNabil M S AmorReza ArdehaliAdriana ArnesonCharles Scott BakerGareth T BanksKatherine BelovNigel Charles BennettPeter BlackDaniel T BlumsteinEleanor K BorsCharles E BreezeRobert T BrookeJanine L BrownGerald G CarterAlex CaultonJulie M CavinLisa ChakrabartiIoulia ChatzistamouAndreas S ChavezHao ChenKaiyang ChengPriscila ChiavelliniOi-Wa ChoiShannon M ClarkeJoseph A CookLisa N CooperMarie-Laurence CossetteJoanna DayJoseph DeYoungStacy DiroccoChristopher DoldJonathan L DunnumErin E EhmkeCandice K EmmonsStephan EmmrichEbru ErbayClaire Erlacher-ReidChris G FaulkesZhe FeiSteven H FergusonCarrie J FinnoJennifer E FlowerJean-Michel GaillardEva GardeLivia GerberVadim N GladyshevRodolfo G GoyaMatthew J GrantCarla B GreenM Bradley HansonDaniel William HartMartin HaulenaKelsey HerrickAndrew N HoganCarolyn J HoggTimothy Alexander HoreTaosheng HuangJuan Carlos Izpisua BelmonteAnna J JasinskaGareth JonesEve JourdainOlga KashpurHarold KatcherEtsuko KatsumataVimala KazaHippokratis KiarisMichael S KoborPaweł KordowitzkiWilliam R KoskiMichael KrützenSoo Bin KwonBrenda LarisonSang-Goo LeeMarianne LehmannJean-François LemaitreAndrew J LevineXinmin LiCun LiAndrea R LimDavid Tse Shen LinDana M LindemannSchuyler W LiphardtThomas J LittleNicholas MacorettaDewey MaddoxCraig O MatkinJulie A MattisonMatthew McClureJune MerglJennifer J MeudtGisele A MontanoKhyobeni MozhuiJason Munshi-SouthWilliam J MurphyAsieh NaderiMartina NagyPritika NarayanPeter W NathanielszNgoc B NguyenChristof NiehrsBatsaikhan NyamsurenJustine K O'BrienPerrie O'Tierney GinnDuncan T OdomAlexander G OphirSteve OsbornElaine A OstranderKim M ParsonsKimberly C PaulAmy B PedersenMatteo PellegriniKatharina J PetersJessica L PetersenDarren W PietersenGabriela M PinhoJocelyn PlassaisJesse R PoganikNatalia A PradoPradeep ReddyBenjamin ReyBeate R RitzJooke RobbinsMagdalena RodriguezJennifer RussellElena RydkinaLindsay L SailerAdam B SalmonAkshay SanghaviKyle M SchachtschneiderDennis SchmittTodd L SchmittLars SchomacherLawrence B SchookKaren E SearsAshley W SeifertAaron B A ShaferAnastasia V ShindyapinaMelanie SimmonsKavita SinghIshani SinhaJesse SloneRussell Grant SnellElham SoltanmohammadiMatthew L SpanglerMaria SpriggsLydia StaggsNancy StedmanKaren J SteinmanDonald T StewartVictoria J SugrueBalazs SzladovitsJoseph S TakahashiMasaki TakasugiEmma C TeelingMichael J ThompsonBill Van BonnSonja C VernesDiego VillarHarry V VintersHa VuMary C WallingfordNan WangGerald S WilkinsonRobert W WilliamsQi YanMingjia YaoBrent G YoungBohan ZhangZhihui ZhangYang ZhaoPeng ZhaoWanding ZhouJoseph Alan ZollerJason ErnstAndrei SeluanovVera GorbunovaXiangdong William YangKenneth RajSteve Horvath
Published in: Science (New York, N.Y.) (2023)
Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.
Keyphrases