MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages.
Ana Lemus-ConejoMayte MedranoSergio Lopez-MartínMaría Del Carmen Millán-LinaresMaria A RosilloJose A Perez-SimonFrancisco J G MurianaRocio AbiaPublished in: Molecular nutrition & food research (2021)
The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems.
Keyphrases
- weight loss
- insulin resistance
- high glucose
- metabolic syndrome
- diabetic rats
- type diabetes
- fatty acid
- single cell
- weight gain
- high fat diet
- high fat diet induced
- physical activity
- drug induced
- bone marrow
- oxidative stress
- cell therapy
- stem cells
- endothelial cells
- genome wide
- gene expression
- skeletal muscle
- dna methylation
- body mass index