An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells.

Yuri Longatto BoteonLorraine WallaceAmanda P C S BoteonDarius F MirzaHynek MergentalRicky H BhogalSimon Afford

Published in: PloS one (2018)

These data demonstrate that pharmacological intervention can significantly decrease intracellular lipid content of PHH, increase fatty acids β-oxidation whilst being non-toxic to PHH, HIEC or cholangiocytes.

Keyphrases

endothelial cells
fatty acid
randomized controlled trial
high glucose
electronic health record
vascular endothelial growth factor
induced pluripotent stem cells
big data
liver injury
pluripotent stem cells
machine learning
nitric oxide
artificial intelligence