Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.

Charis WongJenna M GregoryJing LiaoKieren J EganHanna M VesterinenAimal Ahmad KhanMohammed Ma'arij AnwarCaitlin BeaganFraser S BrownJohn CafferkeyAlessandra CardinaliJane Yi ChiamClaire ChiangVictoria G CollinsJoyce DormidoElizabeth ElliottPeter FoleyYu Cheng FooLily Fulton-HumbleAngus B GaneStella A Glasmacher Áine HeffernanKiran JayaprakashNimesh JayasuriyaAmina KaddouriJamie KiernanGavin LanglandsD LeightonJiaming LiuJames LyonArpan R MehtaAlyssa MengVivienne NguyenNa Hyun ParkSuzanne QuigleyYousuf RashidAndrea SalzingerBethany ShiellAnkur SinghTim SoaneAlexandra ThompsonOlaf TomalaFergal M WaldronBhuvaneish T SelvarajJeremy ChatawayRobert SwinglerPeter ConnickSuvankar Pal Siddharthan Chandran Malcolm Robert MacLeod

Published in: BMJ open (2023)

For future drug selection, we will incorporate automation tools, text-mining and machine learning techniques to the systematic reviews and consider data generated from other domains, including high-throughput phenotypic screening of human iPSCs.

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