Quantitative muscle analysis in facioscapulohumeral muscular dystrophy using whole-body fat-referenced MRI: Protocol development, multicenter feasibility, and repeatability.

Per WidholmAndré AhlgrenMarkus KarlssonThobias RomuRabi TawilKathryn R WagnerJeffrey M StatlandLeo H WangPerry B ShiehBaziel G M van EngelenDiego CadavidLucienne RoncoAdefowope O OdueyungboJohn G JiangMichelle L MellionOlof Dahlqvist Leinhard

Published in: Muscle & nerve (2022)

We developed and validated a method for measuring skeletal muscle volume and fat content for use in multisite clinical trials of neuromuscular disorders.

Keyphrases

muscular dystrophy
skeletal muscle
clinical trial
duchenne muscular dystrophy
randomized controlled trial
adipose tissue
insulin resistance
magnetic resonance imaging
contrast enhanced
high resolution
cross sectional
fatty acid
double blind
computed tomography
type diabetes
phase ii
mass spectrometry