Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis.
Achilleas FloudasConor M SmithOrla TynanNuno NetoVinod KrishnaSarah M WadeMegan HanlonClare CunninghamViviana MarzaioliMary CanavanJean M FletcherRonan H MullanSuzanne ColeLing-Yang HaoMichael G MonaghanSunil NagpalDouglas James VealeUrsula FearonPublished in: Annals of the rheumatic diseases (2022)
invasive synovial fibroblasts, expanded in RA compared with PsA. In vitro characterisation of patient with RA synovial fibroblasts showed metabolic switch to glycolysis, increased adhesion intercellular adhesion molecules 1 expression and IL-6 secretion in response to combined TGF-β and IL-1β treatment. Disrupting specific immune and stromal cell interactions offers novel opportunities for targeted therapeutic intervention in RA and PsA.
Keyphrases
- rheumatoid arthritis
- prostate cancer
- disease activity
- bone marrow
- ankylosing spondylitis
- randomized controlled trial
- poor prognosis
- extracellular matrix
- cell adhesion
- radical prostatectomy
- biofilm formation
- rheumatoid arthritis patients
- single cell
- case report
- interstitial lung disease
- cell therapy
- systemic lupus erythematosus
- transforming growth factor
- binding protein
- cancer therapy
- cell migration
- epithelial mesenchymal transition
- systemic sclerosis
- drug delivery
- mesenchymal stem cells