Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance.

Laura KriegKonrad DidtIsabel KarkossaStephan H BernhartStephanie KehrNarmadha SubramanianAndreas LindhorstAlexander SchaudinnShirin TabeiMaria KellerMichael StumvollArne DietrichMartin Von Bergen Peter F StadlerJurga LaurencikieneMartin KrügerMatthias BlüherMartin GerickeKristin Schubert Peter Kovacs Rima M Chakaroun Lucas Massier

Published in: Gut (2021)

Multi-omics epiAT signatures reflect systemic IR and obesity subphenotypes distinct from other fat depots. Our data suggest a previously unrecognised role of human epiploic fat in the context of obesity, impaired insulin sensitivity and related diseases.

Keyphrases

insulin resistance
adipose tissue
endothelial cells
metabolic syndrome
high fat diet
high fat diet induced
type diabetes
genome wide
weight loss
skeletal muscle
induced pluripotent stem cells
polycystic ovary syndrome
pluripotent stem cells
single cell
weight gain
fatty acid
artificial intelligence