Seleno Containing Compounds as Potent and Selective Antifungal Agents.
Andrea AgeliAlice VelluzziSilvia SelleriClemente CapassoCostanza SpadiniMattia IannarelliClotilde S CabassiFabrizio CartaClaudiu T SupuranPublished in: ACS infectious diseases (2022)
Fungal promoted infections are becoming a severe health global emergency due to drug-resistant phenomena and zoonosis. This work investigated compounds bearing acyl-/selenoureido moieties and primary/secondary sulfonamide groups as novel antifungal agents acting through organism-directed selenium toxicity and inhibition of the newly emergent therapeutic target, the Carbonic Anhydrases (CAs; EC 4.2.1.1). Reported data clearly indicate that seleno-containing scaffolds with respect to the standard-of-care drugs showed appreciable antifungal activity, which was suppressed when the chalcogen was replaced with its cognate isosteric elements sulfur and oxygen. In addition, such compounds showed excellent selectivity against Malassezia pachydermatis over its related genus strains Malassezia furfur and Malassezia globosa . Safe cytotoxicity profiles on bovine kidney cells (MDBK) and human HaCat cells, as well as the shallow hemolytic activity on defibrinated sheep blood, allowed us to consider these compounds as up-and-coming novel antifungals.
Keyphrases
- drug resistant
- induced apoptosis
- healthcare
- public health
- multidrug resistant
- cell cycle arrest
- acinetobacter baumannii
- candida albicans
- endothelial cells
- oxidative stress
- escherichia coli
- mental health
- cell death
- quality improvement
- electronic health record
- cell proliferation
- mass spectrometry
- big data
- cystic fibrosis
- climate change
- pseudomonas aeruginosa
- data analysis
- pain management