Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity.
Zhixin JingPhillip GalboLuis Jose OvandoMegan DemouthSkylar WelteRosa ParkKartik ChandranYinghao WuThomas MacCarthyDeyou ZhengDavid R FooksmanPublished in: bioRxiv : the preprint server for biology (2023)
LLPCs have reduced motility and increased clustering in the BMLLPCs accumulate in the BM PC pool, with mouse ageLLPCs have unique surfaceome, transcriptome, and BCR clonalityCXCR4 controls maintenance of PCs and antibody titers.