Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.
Rana FetitAlistair Stewart McLarenMark WhiteMegan L MillsJohn FalconerXabier Cortes-LavaudKathryn L GilroyTamsin R M LannaganRachel A RidgwayColin NixonVarushka NaikerRenee NjungeCassie J ClarkeDeclan WhyteKristina KirschnerRene JackstadtJames C NormanLeo M CarlinAndrew D CampbellOwen James SansomColin W SteelePublished in: Cancer research communications (2024)
We identify two recurring neutrophil populations and demonstrate their staged evolution from health to malignancy through the IL1β/CXCL8/CXCR2 axis, allowing for immunotherapeutic neutrophil-targeting approaches to counteract immunosuppressive subtypes that emerge in metastasis.