Development of small cyclic peptides targeting the CK2α/β interface.
Eleanor L AtkinsonJessica IegreClaudio D'AmorePaul D BrearMauro SalviMarko HyvönenDavid R SpringPublished in: Chemical communications (Cambridge, England) (2022)
In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2α/β PPI. The lead peptide, P8C9, successfully binds to CK2α at the PPI site, is easily synthesisable and functionalisable, highly stable in serum and small enough to accommodate further optimisation.