Paul D Brear (Paul Brear)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 18

Top Topics

Structural Basis

Wastewater Treatment

Top Venues

Nature communications

Nature chemical biology

Chemical science

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Katrin Fischer, Aleksei Lulla, Tsz Y So, Pehuén Pereyra-Gerber, Matthew I J Raybould, Timo N Kohler, Juan Carlos Yam-Puc, Tomasz S Kaminski, Robert Hughes, Gwendolyn L Pyeatt, Florian Leiss-Maier, Paul D Brear, Nicholas J Matheson, Charlotte M Deane, Marko Hyvönen, James E D Thaventhiran, Florian Hollfelder
Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells. Nature biotechnology (2024)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Maximilian A J Harman, Steven J Stanway, Heather S Scott, Yuliya Demydchuk, Gustavo Arruda Bezerra, Simone Pellegrino, Liuhong Chen, Paul D Brear, Aleksei Lulla, Marko Hyvönen, Paul J Beswick, Michael J Skynner
Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. Journal of medicinal chemistry (2023)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Katherine U Gaynor, Marina Vaysburd, Maximilian A J Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna L Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul D Brear, Aleksei Lulla, Katarzyna A Ciazynska, Veronica T Chang, Joanne Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P Stewart, Andrew Owen, John A G Briggs, Marko Hyvönen, Michael J Skynner, Leo C James
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2. Nature communications 14 (1) (2023)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Maria Reinecke, Paul D Brear, Larsen Vornholz, Benedict-Tilmann Berger, Florian Seefried, Stephanie Wilhelm, Patroklos Samaras, Laszlo Gyenis, David William Litchfield, Guillaume Médard, Susanne Müller, Jürgen Ruland, Marko Hyvönen, Mathias Wilhelm, Bernhard Kuster
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nature chemical biology (2023)
Philipp Knyphausen, Mariana Rangel Pereira, Paul D Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature communications 14 (1) (2023)
Stefanie Neun, Paul D Brear, Eleanor Campbell, Theodora Tryfona, Kamel El Omari, Armin Wagner, Paul Dupree, Marko Hyvönen, Florian Hollfelder
Functional metagenomic screening identifies an unexpected β-glucuronidase. Nature chemical biology 18 (10) (2022)
Eleanor L Atkinson, Jessica Iegre, Claudio D'Amore, Paul D Brear, Mauro Salvi, Marko Hyvönen, David R Spring
Development of small cyclic peptides targeting the CK2α/β interface. Chemical communications (Cambridge, England) 58 (30) (2022)
Eleanor L Atkinson, Jessica Iegre, Paul D Brear, Elizabeth A Zhabina, Marko Hyvönen, David R Spring
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules (Basel, Switzerland) 26 (7) (2021)
Abhishek A Jalan, Douglas Sammon, Jeffrey D Hartgerink, Paul D Brear, Katherine Stott, Samir W Hamaia, Emma J Hunter, Douglas R Walker, Birgit Leitinger, Richard W Farndale
Chain alignment of collagen I deciphered using computationally designed heterotrimers. Nature chemical biology 16 (4) (2020)
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul D Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O' Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical science 11 (39) (2020)
Yassmin Abdelhamid, Paul D Brear, Jack Greenhalgh, Xavier Chee, Taufiq Rahman, Martin Welch
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa. The Journal of biological chemistry 294 (42) (2019)
Jessica Iegre, Paul D Brear, David J Baker, Yaw Sing Tan, Eleanor L Atkinson, Hannah F Sore, Daniel H O' Donovan, Chandra Shekhar Verma, Marko Hyvönen, David R Spring
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical science 10 (19) (2019)
Jessica Iegre, Paul D Brear, Claudia De Fusco, Masao Yoshida, Sophie L Mitchell, Maxim Rossmann, Laura Carro, Hannah F Sore, Marko Hyvönen, David R Spring
Second-generation CK2α inhibitors targeting the αD pocket. Chemical science 9 (11) (2018)