Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT.
Kerstin MudersChristian PilatVanessa DeusterTorsten FrechKarsten KrügerJörn Pons-KühnemannFrank-Christoph MoorenPublished in: Mediators of inflammation (2016)
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p = 0.05; LDH, p = 0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p = 0.02), a trend towards a lower expression of CD69 count (p = 0.07), and antigen-stimulated ICAM-1 (p = 0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p = 0.10), BDNF (p = 0.03), stem cell factor (p = 0.09), and GM-CSF (p = 0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469).
Keyphrases
- double blind
- placebo controlled
- immune response
- clinical trial
- oxidative stress
- skeletal muscle
- phase iii
- phase ii
- stem cells
- protein kinase
- chronic pain
- open label
- high intensity
- study protocol
- physical activity
- dendritic cells
- neuropathic pain
- poor prognosis
- toll like receptor
- phase ii study
- randomized controlled trial
- mental health
- depressive symptoms
- spinal cord
- mass spectrometry
- body composition
- mesenchymal stem cells
- squamous cell carcinoma
- radiation therapy
- spinal cord injury
- social support
- high speed
- long non coding rna
- inflammatory response
- resistance training