DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
Federica QuagliaBálint MészárosEdoardo SalladiniAndras HatosRita PancsaLucía Beatriz ChemesMátyás PajkosTamas LazarSamuel Peña-DíazJaime SantosVeronika ÁcsNazanin FarahiErzsébet FichóMaria Cristina AspromonteClaudio BassotAnastasia ChasapiNorman E DaveyRadoslav DavidovićLászló DobsonArne ElofssonGábor ErdősPascale GaudetMichelle G GiglioJuliana GlavinaJavier IserteValentin IglesiasZsófia KálmánMatteo LambrughiEmanuela LeonardiSonia LonghiSandra Macedo-RibeiroEmiliano MaianiJulia MarchettiCristina Marino-BusljeAttila MészárosAlexander Miguel MonzonGiovanni MinerviniSuvarna NadendlaJuliet F NilssonMarian NovotnýChristos A OuzounisNicolas PalopoliElena PapaleoPedro José Barbosa PereiraGabriele PozzatiVasilis J PromponasJordi PujolsAlma Carolina Sanchez RochaMartin SalasLuciana Rodriguez SawickiEva SchadAditi ShenoyTamás SzaniszlóKonstantinos D TsirigosNevena VeljkovicGustavo ParisiSalvador VenturaZsuzsanna DosztányiPeter TompaSilvio C E TosattoDamiano PiovesanPublished in: Nucleic acids research (2021)
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.