Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma.

Fangming LiuWeiren LiuShuang ZhouChunhui YangMengxin TianGuangshuai JiaHan WangBijun ZhuMingxiang FengYan LuTiankui QiaoXinxin WangWei CaoXiangdong WangYinghong ShiDuojiao Wu

Published in: Journal for immunotherapy of cancer (2021)

The tumor microenvironment can impose metabolic restrictions on T-cell function. CD137, a costimulatory molecule highly expressed on some Tex, uses exogenous fatty acids and oxidative metabolism to mediate antitumor immunity. The immunometabolic marker FABP5 should be investigated in larger, longitudinal studies to determine their potential as prognostic biomarkers for HCC.

Keyphrases

fatty acid
binding protein
endothelial cells
induced pluripotent stem cells
pluripotent stem cells
cross sectional
atomic force microscopy
case control
mass spectrometry
bioinformatics analysis