The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia.
Matthias I GröschelConor Joseph MeehanIvan BarilarMargo DiricksAitor GonzagaMatthias SteglichOscar Conchillo-SoléIsabell-Christin SchererUwe MamatChristian Friedemann LuzKatrien De BruyneChristian UtpatelDaniel YeroIsidre GibertXavier DauraStefanie KampmeierNurdyana Abdul RahmanMichael KreskenTjip S van der WerfIfey AlioWolfgang J StreitKai ZhouThomas SchwartzJohn W A RossenMaha Reda FarhatUlrich E SchaibleUlrich NübelJan RuppJoerg SteinmannStefan NiemannThomas Andreas KohlPublished in: Nature communications (2020)
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
Keyphrases
- multidrug resistant
- endothelial cells
- escherichia coli
- healthcare
- gram negative
- staphylococcus aureus
- induced pluripotent stem cells
- pseudomonas aeruginosa
- genome wide
- pluripotent stem cells
- biofilm formation
- drug resistant
- dna methylation
- single cell
- social media
- cystic fibrosis
- human health
- health information
- transcription factor
- gestational age
- preterm birth
- bioinformatics analysis