Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand.
Jemma L GeogheganXiaoyun RenMatthew StoreyJames HadfieldLauren JelleySarah JefferiesJill SherwoodShevaun PaineQ Sue HuangJordan DouglasFábio K MendesAndrew A SporleMichael G BakerDavid R MurdochNigel P FrenchColin R SimpsonDavid WelchAlexei J DrummondEdward C HolmesSebastián DuchêneJoep de LigtPublished in: Nature communications (2020)
New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide 'lockdown' of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the 'first wave', representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, Re of New Zealand's largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.
Keyphrases
- sars cov
- public health
- respiratory syndrome coronavirus
- copy number
- healthcare
- global health
- randomized controlled trial
- primary care
- coronavirus disease
- genome wide
- systematic review
- climate change
- candida albicans
- placebo controlled
- deep learning
- electronic health record
- mental health
- health insurance
- double blind
- study protocol