Catechols: a new class of carbonic anhydrase inhibitors.

Katia D'Ambrosio Simone Carradori Stefania CesaAndrea AngeliSimona M MontiClaudiu T Supuran Giuseppina De Simone

Published in: Chemical communications (Cambridge, England) (2020)

To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water".

Keyphrases

protein kinase
atomic force microscopy
healthcare
dna binding
transcription factor
binding protein
social media
single molecule