Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations.
Azadeh C BashiElizabeth A CokerKrishna C BulusuPatricia JaaksClaire CrafterHoward LightfootMarta MiloKatrina McCartenDavid F JenkinsDieudonne van der MeerJames T LynchSyd BarthorpeCourtney L AndersenSimon T BarryAlexandra BeckJustin CidadoJacob A GordonCaitlin HallJames A HallIman MaliTatiana MironenkoKevin MongeonJames MorrisLaura RichardsonPaul D SmithOmid TavanaCharlotte TolleyFrances ThomasBrandon S WillisWanjuan YangLenka Oplustil O'ConnorUltan McDermottSusan E CritchlowLisa DrewStephen E FawellJerome T MettetalMathew J GarnettPublished in: Cancer discovery (2024)
We present the largest cancer drug combination screen published to date with 7 × 7 concentration response matrices for 109 combinations in more than 750 cell lines, complemented by multi-omics predictors of response and identification of "emergent" combination biomarkers. We prioritize hits to optimize clinical translatability, and experimentally validate novel combination hypotheses.