Pattern of human monocyte subpopulations in health and disease.
Agnieszka OżańskaDonata SzymczakJustyna RybkaPublished in: Scandinavian journal of immunology (2020)
Monocytes are important cells of the innate system. They are a heterogeneous type of cells consisting of phenotypically and functionally distinct subpopulations, which play a specific role in the control, development and escalation of the immunological processes. Based on the expression of superficial CD14 and CD16 in flow cytometry, they can be divided into three subsets: classical, intermediate and non-classical. Variation in the levels of human monocyte subsets in the blood can be observed in patients in numerous pathological states, such as infections, cardiovascular and inflammatory diseases, cancer and autoimmune diseases. The aim of this review is to summarize current knowledge of human monocyte subsets and their significance in homeostasis and in pathological conditions.
Keyphrases
- endothelial cells
- peripheral blood
- dendritic cells
- induced apoptosis
- flow cytometry
- healthcare
- induced pluripotent stem cells
- pluripotent stem cells
- immune response
- cell cycle arrest
- public health
- poor prognosis
- mental health
- ejection fraction
- squamous cell carcinoma
- randomized controlled trial
- signaling pathway
- cell death
- open label
- study protocol
- long non coding rna
- social media
- squamous cell
- binding protein
- childhood cancer
- patient reported outcomes
- health promotion