Lipidomic signatures align with inflammatory patterns and outcomes in critical illness.
Junru WuAnthony CyrDanielle S GruenTyler C LovelacePanayiotis V BenosJishnu DasUpendra K KarTianmeng ChenFrancis X GuyetteMark H YazerBrian J DaleyRichard S MillerBrian G HarbrechtJeffrey A ClaridgeHerb A PhelanBrian S ZuckerbraunMatthew D NealPär I JohanssonJakob StensballeRami A NamasYoram VodovotzJason L SperryTimothy R Billiarnull nullPublished in: Nature communications (2022)
Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.
Keyphrases
- end stage renal disease
- oxidative stress
- newly diagnosed
- ejection fraction
- drug induced
- fatty acid
- chronic kidney disease
- liver failure
- machine learning
- peritoneal dialysis
- type diabetes
- trauma patients
- metabolic syndrome
- deep learning
- early onset
- patient reported outcomes
- genome wide
- risk assessment
- skeletal muscle
- patient reported
- hepatitis b virus
- glycemic control
- mechanical ventilation