Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome.
Vallijah SubasriNicholas LightNisha KanwarJack J BrzezinskiPing LuoJordan R HansfordElizabeth CairneyCarol PortwineChristine ElserJonathan L FinlayKim E NicholsNoa AlonLedia BrungaJo AnsonWendy K KohlmannKelvin César de AndradePayal P KhinchaSharon A SavageJoshua D SchiffmanRosanna WeksbergTrevor J PughAnita VillaniAdam ShlienAnna GoldenbergDavid MalkinPublished in: Cancer research communications (2023)
. More broadly, it necessitates the dissociation of hereditary cancer syndromes as single gene disorders and emphasizes the importance of understanding these diseases in a holistic manner as opposed to through the lens of a single gene.