Visceral hypersensitivity induced by mild traumatic brain injury via the corticotropin-releasing hormone receptor: An animal model.

Akinori MizoguchiMasaaki HigashiyamaAkinori WadaHiroyuki NishimuraAkira TomiokaSuguru ItoRina TanemotoShin NishiiKenichi InabaNao SugiharaYoshinori HanawaKazuki HoriuchiYoshikiyo OkadaChie KuriharaYoshihiro AkitaKazuyuki NarimatuShunsuke KomotoKengo TomitaSatoko KawauchiShunichi SatoRyota Hokari

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2023)

LISW provoked visceral hypersensitivity, small intestinal hyperpermeability, altered expression of CRFRs and changes in the microbiota, suggesting that genuine bTBI caused by LISW can induce a pathophysiology comparable to that of human IBS.

Keyphrases

mild traumatic brain injury
insulin resistance
endothelial cells
drug induced
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
irritable bowel syndrome
type diabetes
binding protein
skeletal muscle
long non coding rna
adipose tissue