Changes in circulating microRNAs-99/100 and reductions of visceral and ectopic fat depots in response to lifestyle interventions: the CENTRAL trial.

Yoriko HeianzaKnut KrohnQiaochu XueAnat Yaskolka MeirStefanie ZiescheUta CeglarekMatthias BlüherMaria KellerPeter KovacsIris ShaiLu Qi

Published in: The American journal of clinical nutrition (2022)

Decreases in circulating miR-99-5p/100-5p expression induced by lifestyle interventions were related to improved body fat distribution and ectopic fat accumulation. Our study suggests that changes in circulating adipose-related miR-99-5p/100-5p may be linked to reducing diabetogenic fat depots in patients with abdominal obesity.This trial was registered at clinicaltrials.gov as NCT01530724.

Keyphrases

adipose tissue
insulin resistance
physical activity
metabolic syndrome
weight loss
study protocol
phase iii
clinical trial
fatty acid
cardiovascular disease
phase ii
poor prognosis
type diabetes
high fat diet induced
randomized controlled trial
weight gain
open label
double blind