Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses.
Fengfeng LiYang JiaJun FangLinqiang GongYazhou ZhangShanshan WeiFengfeng LiPei JiangPublished in: Drug design, development and therapy (2024)
TBI reduced the expression of MOTS-c. MOTS-c reduced inflammatory responses, molecular damage, and cell death by down-regulating macrophage migration inhibitory factor (MIF) expression and activating the retrograde endocannabinoid signaling pathway. In addition, MOTS-c alleviated the response to hypoxic stress and enhanced lipid β-oxidation to provide energy for the body following TBI. Overall, our study offered new insights into the neuroprotective mechanisms of MOTS-c in TBI mice.
Keyphrases
- traumatic brain injury
- signaling pathway
- severe traumatic brain injury
- cell death
- poor prognosis
- mild traumatic brain injury
- high fat diet induced
- pi k akt
- cerebral ischemia
- adipose tissue
- binding protein
- epithelial mesenchymal transition
- single cell
- long non coding rna
- hydrogen peroxide
- fatty acid
- metabolic syndrome
- type diabetes
- insulin resistance
- nitric oxide
- blood brain barrier
- skeletal muscle
- stress induced