HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line.
Kenneth G-J OoiAnupam RaoJonathan S-K GohGary GracieSvetlana CherepanoffMichele C MadiganStephanie L WatsonPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2019)
HMGCR was expressed in all eyelid sebaceous-type glands and in HMGECs, consistent with a role for cholesterol production in the genesis of tear film lipids. The observed expression also provides a rationale for using topical statins, inhibitors of HMGCR, as novel tear film lipid stabilizers in conditions such as blepharitis, where meibum production is aberrant.