Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care.

Edwin Cuppen Olivier Elemento Richard RosenquistSvetlana NikicMaarten IJzermanIsabelle Durand ZaleskiGeert FrederixLars-Åke Levin Charles G Mullighan Reinhard Buttner Trevor J Pugh Sean M Grimmond Carlos Caldas Fabrice AndreIlse CustersElias CampoHans van SnellenbergAnna Schuh Hidewaki NakagawaChristof von KalleTorsten HaferlachStefan Fröhling Vaidehi Jobanputra

Published in: JCO precision oncology (2022)

WGTS is an appropriate comprehensive clinical test for many tumor types and can replace multiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number of clinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave the way for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosis and treatment for patients with cancer.

Keyphrases

healthcare
single cell
clinical practice
primary care
quality improvement
gene expression
rna seq
high throughput
small molecule
copy number
dna methylation
health information
affordable care act