Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome.
Wei Wen LimJinrui DongBenjamin NgAnissa Anindya WidjajaChen XieLiping SuXiu-Yi KwekNicole G Z TeeChee Jian PuaSebastian SchaferSivakumar ViswanathanStuart Alexander CookPublished in: Circulation research (2022)
In MFS, IL11 is upregulated in aortic VSMCs to cause ERK-related thoracic aortic dilatation, inflammation, and fibrosis. Therapeutic inhibition of IL11, imminent in clinical trials, might be considered as a new approach in MFS.