Clinicopathologic, genomic, and immunophenotypic landscape of ATM mutations in non-small cell lung cancer.

Biagio Ricciuti Arielle Elkrief Joao M Victor Alessi Xinan Wang Yvonne Y Li Hersh V Gupta Daniel M Muldoon Arrien A Bertram Federica Pecci Giuseppe Lamberti Alessandro Di Federico Adriana P Barrichello Victor R Vaz Malini M Gandhi Elinton Lee Geoffrey I Shapiro Hyesun Park Mizuki Nishino James R Lindsay Kristen D Felt Bijaya Sharma Andrew D Cherniak Scott J Rodig Daniel R Gomez Narek Shaverdian Mehrdad Rakaee Chaitanya Bandlamudi Marc Ladanyi Pasi A Janne Adam J Schoenfeld Lynette M Sholl Mark M Awad Michael L Cheng

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Deleterious ATM mutations defined a subset of NSCLC with unique clinicopathologic, genomic, and immunophenotypic features. Our data may serve as resource to guide interpretation of specific ATM mutations in NSCLC.

Keyphrases

dna damage
small cell lung cancer
dna damage response
dna repair
copy number
advanced non small cell lung cancer
oxidative stress
big data
electronic health record
machine learning
deep learning
epidermal growth factor receptor