Biotransformation of Cacumen platycladi Extract by Lactiplantibacillus plantarum CCFM1348 Promotes Hair Growth in Mice.
Xin TangTongtong ZhangBotao WangBingyong MaoQiuxiang ZhangJianxin ZhaoWei ChenShumao CuiPublished in: Journal of agricultural and food chemistry (2024)
Cacumen platycladi (CP) is a frequently used traditional Chinese medicine to treat hair loss. In this study, CP fermented by Lactiplantibacillus plantarum CCFM1348 increased the proliferation of human dermal papilla cells. In an in vivo assay, compared to nonfermented CP, postbiotics (fermented CP) and synbiotics (live bacteria with nonfermented CP) promoted hair growth in mice. The Wnt/β-catenin signaling pathway plays crucial roles in the development of hair follicles, including growth cycle restart and maintenance. Both postbiotics and synbiotics upregulated β-catenin, a major factor of the Wnt/β-catenin signaling pathway. Postbiotics and synbiotics also increased the vascular endothelial growth factor expression and decreased the BAX/Bcl2 ratio in the dorsal skin of mice. These results suggest that fermented CP by L. plantarum CCFM1348 may promote hair growth through regulating the Wnt/β-catenin signaling pathway, promoting the expression of growth factors and reducing apoptosis.
Keyphrases
- vascular endothelial growth factor
- cell proliferation
- stem cells
- induced apoptosis
- poor prognosis
- oxidative stress
- cell cycle arrest
- endothelial cells
- endoplasmic reticulum stress
- cell death
- type diabetes
- signaling pathway
- binding protein
- epithelial mesenchymal transition
- long non coding rna
- high throughput
- lactic acid
- metabolic syndrome
- wild type
- spinal cord injury
- soft tissue
- anti inflammatory