KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.
Thomas MühlenbergJohanna FalkenhorstTom SchulzBenjamin S FletcherAlina TeuberDawid KrzeciesaIsabella KloosterMeijun Z LundbergLydia WilsonJonas LategahnMargaret von MehrenSusanne GrunewaldAlicia Isabell TünsEva WardelmannJason K SicklickMehdi BrahmiCésar SerranoHans-Ulrich SchildhausSonja SieversJürgen TreckmannMichael C HeinrichChandrajit P RautWen-Bin OuAdrian Mariño-EnriquezSuzanne GeorgeDaniel RauhJonathan A FletcherSebastian BauerPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
mutations. However, the emergence of KIT AP/AL mutations after ripretinib treatment calls for new strategies in the development of next-generation KIT inhibitors.