Daniel Rauh (D Rauh)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 57

Top Topics

Epidermal Growth Factor Receptor

Top Venues

Journal of medicinal chemistry

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Nature communications

Angewandte Chemie (International ed. in English)

This page only lists publications with an associated author ORCID identifier.

Publications

Alina Teuber, Tom Schulz, B S Fletcher, Rajesh Gontla, Thomas Mühlenberg, M-L Zischinsky, Janina Niggenaber, Jörn Weisner, S B Kleinbölting, Jonas Lategahn, Sonja Sievers, Matthias Philipp Müller, Sebastian Bauer, Daniel Rauh
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nature communications 15 (1) (2024)
Kosmas Alexandros Pervanidis, Giovanni Danilo D'Angelo, Jörn Weisner, Sven Brandherm, Daniel Rauh
Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises. Journal of medicinal chemistry 67 (8) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Alina Teuber, Tom Schulz, B S Fletcher, Rajesh Gontla, Thomas Mühlenberg, M-L Zischinsky, Janina Niggenaber, Jörn Weisner, S B Kleinbölting, Jonas Lategahn, Sonja Sievers, Matthias Philipp Müller, Sebastian Bauer, Daniel Rauh
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nature communications 15 (1) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Tonia Kirschner, Matthias Philipp Müller, Daniel Rauh
Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy. Journal of medicinal chemistry (2024)
Sebastian Bauer, Jonathan A Fletcher, Daniel Rauh, Johanna Falkenhorst, Thomas Mühlenberg
Reply to Y. Xia et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Alina Teuber, Tom Schulz, B S Fletcher, Rajesh Gontla, Thomas Mühlenberg, M-L Zischinsky, Janina Niggenaber, Jörn Weisner, S B Kleinbölting, Jonas Lategahn, Sonja Sievers, Matthias Philipp Müller, Sebastian Bauer, Daniel Rauh
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nature communications 15 (1) (2024)
Kosmas Alexandros Pervanidis, Giovanni Danilo D'Angelo, Jörn Weisner, Sven Brandherm, Daniel Rauh
Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises. Journal of medicinal chemistry (2024)
Alina Teuber, Tom Schulz, B S Fletcher, Rajesh Gontla, Thomas Mühlenberg, M-L Zischinsky, Janina Niggenaber, Jörn Weisner, S B Kleinbölting, Jonas Lategahn, Sonja Sievers, Matthias Philipp Müller, Sebastian Bauer, Daniel Rauh
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nature communications 15 (1) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Tonia Kirschner, Matthias Philipp Müller, Daniel Rauh
Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy. Journal of medicinal chemistry 67 (8) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Dawid Krzeciesa, Isabella Klooster, Meijun Z Lundberg, Lydia Wilson, Jonas Lategahn, Margaret von Mehren, Susanne Grunewald, Alicia Isabell Tüns, Eva Wardelmann, Jason K Sicklick, Mehdi Brahmi, César Serrano, Hans-Ulrich Schildhaus, Sonja Sievers, Jürgen Treckmann, Michael C Heinrich, Chandrajit P Raut, Wen-Bin Ou, Adrian Mariño-Enriquez, Suzanne George, Daniel Rauh, Jonathan A Fletcher, Sebastian Bauer
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (12) (2024)
Tobias Grabe, Kirujan Jeyakumar, Janina Niggenaber, Tom Schulz, Sandra Koska, Silke Kleinbölting, Michael Edmund Beck, Matthias Philipp Müller, Daniel Rauh
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. ACS medicinal chemistry letters 14 (5) (2023)
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias Philipp Müller, Daniel Rauh
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. eLife 12 (2023)
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias Philipp Müller, Daniel Rauh
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. eLife 12 (2023)
Juliane Stehle, Jörn Weisner, Leanne Eichhorn, Daniel Rauh, Malte Drescher
Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany) (2023)
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias Philipp Müller, Daniel Rauh
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. eLife 12 (2023)
Mike Bührmann, Shivakrishna Kallepu, Jonas D Warmuth, Jan N Wiese, Christiane Ehrt, Helge Vatheuer, Wolf Hiller, Carina Seitz, Laura Levy, Paul Czodrowski, Sonja Sievers, Matthias Philipp Müller, Daniel Rauh
Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. Journal of medicinal chemistry 66 (9) (2023)
Mike Bührmann, Shivakrishna Kallepu, Jonas D Warmuth, Jan N Wiese, Christiane Ehrt, Helge Vatheuer, Wolf Hiller, Carina Seitz, Laura Levy, Paul Czodrowski, Sonja Sievers, Matthias Philipp Müller, Daniel Rauh
Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. Journal of medicinal chemistry (2023)
Mike Bührmann, Shivakrishna Kallepu, Jonas D Warmuth, Jan N Wiese, Christiane Ehrt, Helge Vatheuer, Wolf Hiller, Carina Seitz, Laura Levy, Paul Czodrowski, Sonja Sievers, Matthias Philipp Müller, Daniel Rauh
Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. Journal of medicinal chemistry 66 (9) (2023)
Tobias Grabe, Kirujan Jeyakumar, Janina Niggenaber, Tom Schulz, Sandra Koska, Silke Kleinbölting, Michael Edmund Beck, Matthias Philipp Müller, Daniel Rauh
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. ACS medicinal chemistry letters 14 (5) (2023)
Shubhendu Palei, Jörn Weisner, Melina Vogt, Rajesh Gontla, Benjamin C Buchmuller, Christiane Ehrt, Tobias Grabe, Silke Kleinbölting, Matthias Philipp Müller, Guido H Clever, Daniel Rauh, Daniel Summerer
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2. RSC medicinal chemistry 13 (12) (2022)
Paul Gehrtz, Shir Marom, Mike Bührmann, Julia Hardick, Silke Kleinbölting, Amit Shraga, Christian Dubiella, Ronen Gabizon, Jan N Wiese, Matthias Philipp Müller, Galit Cohen, Ilana Babaev, Khriesto Shurrush, Liat Avram, Efrat Resnick, Haim Barr, Daniel Rauh, Nir London
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. Journal of medicinal chemistry 65 (15) (2022)
Heike Chauvistré, Batool Shannan, Sheena M Daignault-Mill, Robert J Ju, Daniel Picard, Stefanie Egetemaier, Renata Varaljai, Christine S Gibhardt, Antonio Sechi, Farnusch Kaschani, Oliver Keminer, Samantha J Stehbens, Jingjing Liu, Xiangfan Yin, Kirujan Jeyakumar, Felix C E Vogel, Clemens Krepler, Vito W Rebecca, Linda Kubat, Smiths S Lueong, Jan Forster, Susanne Horn, Marc Remke, Michael Ehrmann, Annette Paschen, Jürgen Christian Becker, Iris Helfrich, Daniel Rauh, Markus Kaiser, Sheraz Gul, Meenhard Herylyn, Ivan Bogeski, José Neptuno Rodríguez-López, Nikolas K Haass, Dirk Schadendorf, Alexander Roesch
Persister state-directed transitioning and vulnerability in melanoma. Nature communications 13 (1) (2022)
Bianca Wiedemann, Dominic Kamps, Laura Depta, Jörn Weisner, Jana Cvetreznik, Stefano Tomassi, Sascha Gentz, Jan-Erik Hoffmann, Matthias P Müller, Oliver Koch, Leif Dehmelt, Daniel Rauh
Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions. PloS one 17 (6) (2022)
Shubhendu Palei, Jörn Weisner, Melina Vogt, Rajesh Gontla, Benjamin C Buchmuller, Christiane Ehrt, Tobias Grabe, Silke Kleinbölting, Matthias Philipp Müller, Guido H Clever, Daniel Rauh, Daniel Summerer
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2. RSC medicinal chemistry 13 (12) (2022)
Jonas Lategahn, Hannah L Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias Philipp Müller, Johannes M Heuckmann, Bert M Klebl, Peter Nussbaumer, Martin L Sos, Daniel Rauh
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. Journal of medicinal chemistry 65 (9) (2022)
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P Müller, Jens Thomas Siveke, Daniel Rauh
Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nature communications 12 (1) (2021)
Patrick Roser, Jörn Weisner, Juliane Stehle, Daniel Rauh, Malte Drescher
Conformational selection vs. induced fit: insights into the binding mechanisms of p38α MAP Kinase inhibitors. Chemical communications (Cambridge, England) 56 (62) (2021)
Lisa Goebel, Matthias Philipp Müller, Roger S Goody, Daniel Rauh
KRasG12C inhibitors in clinical trials: a short historical perspective. RSC medicinal chemistry 11 (7) (2020)
Susanne Grunewald, Lillian R Klug, Thomas Mühlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Juergen Treckmann, Jonathan A Fletcher, Sascha Jung, Paul Czodrowski, Stephen Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C Heinrich, Sebastian Bauer
Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain. Cancer discovery 11 (1) (2020)
Niklas Uhlenbrock, Steven Smith, Jörn Weisner, Ina Landel, Marius Lindemann, Thien Anh Le, Julia Hardick, Rajesh Gontla, Rebekka Scheinpflug, Paul Czodrowski, Petra Janning, Laura Depta, Lena Quambusch, Matthias Philipp Müller, Bernd Engels, Daniel Rauh
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chemical science 10 (12) (2019)
Patrik Wolle, Matthias Philipp Müller, Daniel Rauh
Augmented Reality in Scientific Publications-Taking the Visualization of 3D Structures to the Next Level. ACS chemical biology 13 (3) (2019)
Janina Niggenaber, Julia Hardick, Jonas Lategahn, Daniel Rauh
Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases. Journal of medicinal chemistry 63 (1) (2019)
Jonas Lategahn, Marina Keul, Philip Klövekorn, Hannah L Tumbrink, Janina Niggenaber, Matthias Philipp Müller, Luke Hodson, Maren Flaßhoff, Julia Hardick, Tobias Grabe, Julian Engel, Carsten Schultz-Fademrecht, Matthias Baumann, Julia Ketzer, Thomas Mühlenberg, Wolf Hiller, Georgia Günther, Anke Unger, Heiko Müller, Alena Heimsoeth, Christopher Golz, Bernhard Blank-Landeshammer, Laxmikanth Kollipara, René Peiman Zahedi, Carsten Strohmann, Jan G Hengstler, Willem A L van Otterlo, Sebastian Bauer, Daniel Rauh
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chemical science 10 (46) (2019)
Jörn Weisner, Ina Landel, Christoph Reintjes, Niklas Uhlenbrock, Marija Trajkovic-Arsic, Niklas Dienstbier, Julia Hardick, Swetlana Ladigan, Marius Lindemann, Steven Smith, Lena Quambusch, Rebekka Scheinpflug, Laura Depta, Rajesh Gontla, Anke Unger, Matthias Philipp Müller, Matthias Baumann, Carsten Schultz-Fademrecht, Georgia Günther, Abdelouahid Maghnouj, Michael Pohl, Christian Teschendorf, Heiner Wolters, Richard Viebahn, Andrea Tannapfel, Waldemar Uhl, Jan G Hengstler, Stephan A Hahn, Jens Thomas Siveke, Daniel Rauh
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer. Cancer research 79 (9) (2019)
Patrik Wolle, Julia Hardick, Shane J F Cronin, Julian Engel, Matthias Baumann, Jonas Lategahn, Josef M Penninger, Daniel Rauh
Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. Journal of medicinal chemistry 62 (5) (2019)
Patrik Wolle, Julian Engel, Steven Smith, Lisa Goebel, Elisabeth Hennes, Jonas Lategahn, Daniel Rauh
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). Journal of medicinal chemistry 62 (11) (2019)
Patrik Wolle, Matthias Philipp Müller, Daniel Rauh
Augmented Reality in Scientific Publications - Taking the Visualization of 3D Structures to the Next Level. ACS chemical biology 15 (1) (2019)
Lena Quambusch, Ina Landel, Laura Depta, Jörn Weisner, Niklas Uhlenbrock, Matthias P Müller, Franziska Glanemann, Kristina Althoff, Jens Thomas Siveke, Daniel Rauh
Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angewandte Chemie (International ed. in English) 58 (52) (2019)
Jonas Lategahn, Marina Keul, Daniel Rauh
Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer. Angewandte Chemie (International ed. in English) 57 (9) (2018)
Roberta Tesch, Christian Becker, Matthias Philipp Müller, Michael Edmund Beck, Lena Quambusch, Matthäus Getlik, Jonas Lategahn, Niklas Uhlenbrock, Fanny Nascimento Costa, Marcelo D Polêto, Pedro de Sena Murteira Pinheiro, Daniel Alencar Rodrigues, Carlos Mauricio R Sant'Anna, Fabio Furlan Ferreira, Hugo Verli, Carlos Alberto Manssour Fraga, Daniel Rauh
An Unusual Intramolecular Halogen Bond Guides Conformational Selection. Angewandte Chemie (International ed. in English) 57 (31) (2018)
Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N Fischer, Matthias Scheffler, Michaela A Ihle, Vanessa Priesner, Andreas H Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F Smit, Sabine Merkelbach-Bruse, H Christian Reinhardt, Stefan M Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L Sos
Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors. Nature communications 9 (1) (2018)
Patrik Wolle, Jörn Weisner, Marina Keul, Ina Landel, Jonas Lategahn, Daniel Rauh
RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics. ChemMedChem 13 (19) (2018)
Martin Schmidt, Alina Romanovska, Youssef Wolf, Thanh-Duong Nguyen, Anna Krupp, Hannah L Tumbrink, Jonas Lategahn, Jan Volmer, Daniel Rauh, Stephan Luetz, Christian Krumm, Joerg Christian Tiller
Insights into the Kinetics of the Resistance Formation of Bacteria against Ciprofloxacin Poly(2-methyl-2-oxazoline) Conjugates. Bioconjugate chemistry 29 (8) (2018)
Bianca Wiedemann, Jörn Weisner, Daniel Rauh
Chemical modulation of transcription factors. MedChemComm 9 (8) (2018)
Mike Bührmann, Bianca M Wiedemann, Matthias P Müller, Julia Hardick, Maria Ecke, Daniel Rauh
Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK. PloS one 12 (9) (2017)
Niklas M Walter, Heike K Wentsch, Mike Bührmann, Silke M Bauer, Eva Döring, Svenja Mayer-Wrangowski, Adrian Sievers-Engler, Nicole Willemsen-Seegers, Guido Zaman, Rogier Buijsman, Michael Lämmerhofer, Daniel Rauh, Stefan A Laufer
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. Journal of medicinal chemistry 60 (19) (2017)
Mike Bührmann, Julia Hardick, Jörn Weisner, Lena Quambusch, Daniel Rauh
Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants. Angewandte Chemie (International ed. in English) 56 (43) (2017)
Stefano Tomassi, Jonas Lategahn, Julian Engel, Marina Keul, Hannah L Tumbrink, Julia Ketzer, Thomas Mühlenberg, Matthias Baumann, Carsten Schultz-Fademrecht, Sebastian Bauer, Daniel Rauh
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor. Journal of medicinal chemistry 60 (6) (2017)
Julian Engel, Steven Smith, Jonas Lategahn, Hannah L Tumbrink, Lisa Goebel, Christian Becker, Elisabeth Hennes, Marina Keul, Anke Unger, Heiko Müller, Matthias Baumann, Carsten Schultz-Fademrecht, Georgia Günther, Jan G Hengstler, Daniel Rauh
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor. Journal of medicinal chemistry 60 (18) (2017)
Marcel Günther, Jonas Lategahn, Michael Juchum, Eva Döring, Marina Keul, Julian Engel, Hannah L Tumbrink, Daniel Rauh, Stefan A Laufer
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site. Journal of medicinal chemistry 60 (13) (2017)
Helena Kaitsiotou, Marina Keul, Julia Hardick, Thomas Mühlenberg, Julia Ketzer, Christiane Ehrt, Jasmin Krüll, Federico Medda, Oliver Koch, Fabrizio Giordanetto, Sebastian Bauer, Daniel Rauh
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT. Journal of medicinal chemistry 60 (21) (2017)