DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.

Adriana YamaguchiLivia StangerCody J FreedmanMelissa StandleyTimothy HoangReheman AdiliWan-Chen TsaiChristopher van HoorebekeTheodore R HolmanMichael A Holinstat

Published in: Journal of thrombosis and haemostasis : JTH (2020)

This study provides the first mechanistic evidence of how DHA and its 12-LOX oxylipins inhibit platelet activity and thrombus formation. These findings support the beneficial effects of DHA as therapeutic intervention in atherothrombotic diseases.

Keyphrases

fatty acid
signaling pathway
randomized controlled trial
pi k akt
epithelial mesenchymal transition
low density lipoprotein
induced apoptosis
cell proliferation