Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer.
Kimberly R HagelRand ArafehSydney GangTaylor E ArnoffRebecca C LarsonJohn G DoenchNathan D MathewsonKai W WucherpfennigMarcela V MausWilliam C HahnPublished in: Cancer research (2023)
The identification and validation of key determinants of CAR T-cell response in pancreatic cancer provide insights into the landscape of tumor cell intrinsic resistance mechanisms and into approaches to improve therapeutic efficacy.