John G Doench (John Doench)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 124

Top Venues

Nature communications

Nature genetics

Proceedings of the National Academy of Sciences of the United States of America

Nature

This page only lists publications with an associated author ORCID identifier.

Publications

Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature (2024)
Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart
Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform. Nature communications 15 (1) (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature 630 (8015) (2024)
Sarah A Weiss, Amy Y Huang, Megan E Fung, Daniela Martinez, Alex C Y Chen, Thomas J LaSalle, Brian C Miller, Christopher D Scharer, Mudra Hegde, Thao H Nguyen, Jared H Rowe, Jossef F Osborn, Dillon G Patterson, Natalia Sifnugel, C Mei-An Nolan, Richard A Davidson, Marc Andre Schwartz, Alexander P R Bally, Dennis K Neeld, Martin W LaFleur, Jeremy M Boss, John G Doench, W Nicholas Haining, Arlene H Sharpe, Debattama R Sen
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control. Nature immunology (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature 630 (8015) (2024)
Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart
Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G Doench, Arunasalam Naguleswaran, Denis Joly, Martín González Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker T Heussler, Sven Rottenberg, Philipp Olias
Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Nature communications 15 (1) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart
Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform. Nature communications 15 (1) (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature 630 (8015) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G Doench, Arunasalam Naguleswaran, Denis Joly, Martín González Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker T Heussler, Sven Rottenberg, Philipp Olias
Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature (2024)
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G Doench, Arunasalam Naguleswaran, Denis Joly, Martín González Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker T Heussler, Sven Rottenberg, Philipp Olias
Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Nature communications 15 (1) (2024)
Qingyu Luo, Evangeline G Raulston, Miguel A Prado, Xiaowei Wu, Kira Gritsman, Karley S Whalen, Kezhi Yan, Christopher A G Booth, Ran Xu, Peter van Galen, John G Doench, Shai Shimony, Henry W Long, Donna S Neuberg, Joao A Paulo, Andrew A Lane
Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart
Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y Juan, Jason W Pyrdol, Oleksandr Kyrysyuk, John G Doench, X Shirley Liu, Kai W Wucherpfennig
Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. Cancer discovery (2023)
Abby V McGee, Yanjing V Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W Miller, Ryan J Steger, Berta Escude Velasco, Justin A Bosch, Jonathan D Zirin, Raghuvir Viswanatha, Erik J Sontheimer, Amy Goodale, Matthew A Greene, Thomas M Green, John G Doench
Modular vector assembly enables rapid assessment of emerging CRISPR technologies. bioRxiv : the preprint server for biology (2023)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer research 83 (4) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Kathryn Gunn, Matti Myllykoski, John Z Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H Diplas, Michael M Levitt, Ryan E Looper, John G Doench, Keith L Ligon, Harley I Kornblum, Samuel K McBrayer, Hai Yan, Cihangir Duy, Lucy A Godley, Peppi Karppinen, Julie-Aurore Losman
(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers. Cancer discovery (2023)
Azucena Ramos, Catherine E Koch, Yunpeng Liu-Lupo, Riley D Hellinger, Taeyoon Kyung, Keene L Abbott, Julia Fröse, Daniel Goulet, Khloe S Gordon, Keith P Eidell, Paul Leclerc, Charles A Whittaker, Rebecca C Larson, Audrey J Muscato, Kathleen B Yates, Juan Dubrot, John G Doench, Aviv Regev, Matthew G Vander Heiden, Marcela V Maus, Robert T Manguso, Michael E Birnbaum, Michael T Hemann
Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Nature communications 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer research 83 (4) (2023)
Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y Juan, Jason W Pyrdol, Oleksandr Kyrysyuk, John G Doench, X Shirley Liu, Kai W Wucherpfennig
Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. Cancer discovery (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Florian Perner, Eytan M Stein, Daniela V Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A Gamlen, Aaron James Stonestrom, Sonali Persaud, Elizabeth T Ener, Jevon A Cutler, John G Doench, Gerard M McGeehan, Andrea Volkamer, John D Chodera, Radosław P Nowak, Eric S Fischer, Ross L Levine, Scott A Armstrong, Sheng F Cai
MEN1 mutations mediate clinical resistance to menin inhibition. Nature (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Fadi J Najm, Peter C DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, Amanda L Waterbury, Brian B Liau, Peter van Galen, John G Doench, Bradley E Bernstein
Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature communications 14 (1) (2023)
Martin W LaFleur, Ashlyn M Lemmen, Ivy S L Streeter, Thao H Nguyen, Lauren E Milling, Nicole M Derosia, Zachary M Hoffman, Jacob E Gillis, Qin Tjokrosurjo, Samuel C Markson, Amy Y Huang, Praju V Anekal, Paula Montero Llopis, W Nicholas Haining, John G Doench, Arlene H Sharpe
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system. Nature immunology (2023)
Jin Wei, Ajinkya Patil, Clayton K Collings, Mia Madel Alfajaro, Yu Liang, Wesley L Cai, Madison S Strine, Renata B Filler, Peter C DeWeirdt, Ruth E Hanna, Bridget L Menasche, Arya Ökten, Mario A Peña-Hernández, Jonathan Klein, Andrew McNamara, Romel Rosales, Briana L McGovern, M Luis Rodriguez, Adolfo García-Sastre, Kris M White, Yiren Qin, John G Doench, Qin Yan, Akiko Iwasak, Thomas P Zwaka, Jun Qi, Cigall Kadoch, Craig B Wilen
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature genetics 55 (3) (2023)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer research 83 (4) (2023)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer research 83 (4) (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Jonas Samuel Jutzi, Anna E Marneth, Michele Ciboddo, Angel Guerra-Moreno, María José Jiménez-Santos, Anastasia Kosmidou, James W Dressman, Hongyan Liang, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fátima Al-Shahrour, Ann Mullally
Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs. Blood 140 (11) (2022)
Juan Dubrot, Peter P Du, Sarah Kate Lane-Reticker, Emily A Kessler, Audrey J Muscato, Arnav Mehta, Samuel S Freeman, Peter M Allen, Kira E Olander, Kyle M Ockerman, Clara H Wolfe, Fabius Wiesmann, Nelson H Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M Schneider, Andrea N Rivera-Rosario, Ian C Kohnle, Hans W Pope, Austin Ayer, Gargi Mishra, Margaret D Zimmer, Sarah Y Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T Frederick, Genevieve M Boland, W Nicholas Haining, David E Root, John G Doench, Nir Hacohen, Kathleen B Yates, Robert T Manguso
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nature immunology 23 (10) (2022)
Eshini Panditharatna, Joana G Marques, Tingjian Wang, Maria C Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V Dharia, Deyao Li, Samantha E Hoffman, Guillaume Kugener, McKenzie L Shaw, Hafsa M Mire, Olivia A Hack, Joshua M Dempster, Caleb A Lareau, Lingling Dai, Logan H Sigua, Michael A Quezada, Ann-Catherine J Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Frederica Piccioni, John G Doench, David E Root, Jamie N Anastas, Kristen L Jones, Amy Saur Conway, Sylwia A Stopka, Michael S Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P Jerome, Nathan D Mathewson, Sirano Dhe-Paganon, Mario L Suvà, Angel Montero Carcaboso, Cinzia Lavarino, Jaume Catala-Mora, Quang-De Nguyen, Keith L Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y R Agar, Kimberly Stegmaier, Charles D Stiles, Michelle Monje, Todd R Golub, Jun Qi, Mariella G Filbin
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer discovery 12 (12) (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Francois Emile Mercier, Jiantao Shi, David Brian Sykes, Toshihiko Oki, Maja Jankovic, Cheuk-Him Man, Youmna S Kfoury, Elizabeth Miller, Shutao He, Alexander Zhu, Radovan Vasic, John G Doench, Alexandre Orthwein, Franziska Michor, David T Scadden
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Blood advances 6 (17) (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer. Cancer research (2022)
Kimberly R Hagel, Rand Arafeh, Sydney Gang, Taylor E Arnoff, Rebecca C Larson, John G Doench, Nathan D Mathewson, Kai W Wucherpfennig, Marcela V Maus, William C Hahn
Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer. Cancer research (2022)
Xiaojian Shi, Bryn Reimer, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E Calvo, Olga Goldberger, John G Doench, Vamsi K Mootha, Hongying Shen
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nature communications 13 (1) (2022)
Matthew G Rees, Lisa Brenan, Mariana do Carmo, Patrick Duggan, Besnik Bajrami, Michael Arciprete, Andrew S Boghossian, Emma Vaimberg, Steven J Ferrara, Timothy A Lewis, Danny Rosenberg, Tenzin Sangpo, Jennifer A Roth, Virendar K Kaushik, Federica Piccioni, John G Doench, David E Root, Cory M Johannessen
Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature chemical biology 18 (6) (2022)
Annabel K Sangree, Audrey L Griffith, Zsofia M Szegletes, Priyanka Roy, Peter C DeWeirdt, Mudra Hegde, Abby V McGee, Ruth E Hanna, John G Doench
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2. Nature communications 13 (1) (2022)
Nicholas Z Lue, Emma M Garcia, Kevin Chun-Ho Ngan, Ceejay Lee, John G Doench, Brian B Liau
Base editor scanning charts the DNMT3A activity landscape. Nature chemical biology (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M Moore, Jian Cui, Chenyi Xue, Katherine R Croce, Arif Yurdagul, John G Doench, Wei Li, Konstantinos S Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Nature communications 13 (1) (2022)
Hao Shi, John G Doench, Hongbo Chi
CRISPR screens for functional interrogation of immunity. Nature reviews. Immunology (2022)
Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench
Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. Nature communications 13 (1) (2022)
Alexis R Gibson, Adam Sateriale, Jennifer E Dumaine, Julie B Engiles, Ryan D Pardy, Jodi A Gullicksrud, Keenan M O'Dea, John G Doench, Daniel P Beiting, Christopher A Hunter, Boris Striepen
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS pathogens 18 (5) (2022)
Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadão, Lowiese Desmarets, Mary Arnaud-Arnould, Yves Rouillé, Marine Tauziet, Donatella Giovannini, Jawida Touhami, Yenarae Lee, Peter DeWeirdt, Mudra Hegde, Serge Urbach, Khadija El Koulali, Francisco Garcia de Gracia, Joe McKellar, Jean Dubuisson, Mélanie Wencker, Sandrine Belouzard, Olivier Moncorgé, John G Doench, Caroline Goujon
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nature genetics 54 (8) (2022)
Hsiao-Yun Chen, Yavuz T Durmaz, Yixiang Li, Amin H Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G Doench, Navin R Mahadevan, Julie-Aurore Losman, David A Barbie, Michael Y Tolstorukov, Charles M Rudin, Triparna Sen, Sabina Signoretti, Matthew G Oser
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1. Nature communications 13 (1) (2022)
Daniel P Bondeson, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E Surface, Kentaro Ito, Mariya Kazachkova, William N Colgan, Allison Warren, Joshua M Dempster, John Michael Krill-Burger, Maria Ericsson, Andrew A Tang, Iris Fung, Emily S Chambers, Mai Abdusamad, Nancy Dumont, John G Doench, Federica Piccioni, David E Root, Jesse S Boehm, William C Hahn, Michael Mannstadt, James M McFarland, Francisca Vazquez, Todd R Golub
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nature cancer 3 (6) (2022)
Caroline Goujon, Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Chaves Valadao, Lowiese Desmarets, Yves Rouillé, Marine Tauziet, Mary Arnaud-Arnould, Donatella Giovannini, Yenarae Lee, Peter DeWeirdt, Mudra Hegde, Francisco Garcia de Gracia, Joe McKellar, Mélanie Wencker, Jean Dubuisson, Sandrine Belouzard, Olivier Moncorgé, John G Doench
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Research square (2021)
Dale R Balce, Ya-Ting Wang, Michael R McAllaster, Bria F Dunlap, Anthony Orvedahl, Barry L Hykes, Lindsay Droit, Scott A Handley, Craig B Wilen, John G Doench, Robert C Orchard, Christina L Stallings, Herbert W Virgin
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proceedings of the National Academy of Sciences of the United States of America 118 (1) (2021)
Walter F Lenoir, Micaela Morgado, Peter C DeWeirdt, Megan McLaughlin, Audrey L Griffith, Annabel K Sangree, Marissa N Feeley, Nazanin Esmaeili Anvar, Eiru Kim, Lori L Bertolet, Medina Colic, Merve Dede, John G Doench, Traver Hart
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells. Nature communications 12 (1) (2021)
Sushil Kumar, Zexian Zeng, Archis Bagati, Rong En Tay, Lionel A Sanz, Stella R Hartono, Yoshinaga Ito, Fieda Abderazzaq, Elodie Hatchi, Peng Jiang, Adam N R Cartwright, Olamide Olawoyin, Nathan D Mathewson, Jason W Pyrdol, Mamie Z Li, John G Doench, Matthew A Booker, Michael Y Tolstorukov, Stephen J Elledge, Frédéric Chédin, X Shirley Liu, Kai W Wucherpfennig
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. Cancer discovery 11 (8) (2021)
Takahiro Ito, Michael J Young, Ruitong Li, Sidharth S Jain, Andreas Wernitznig, John Michael Krill-Burger, Christopher T Lemke, Davide Monducci, Diego J Rodriguez, Liang Chang, Sanjukta Dutta, Debjani Pal, Brenton R Paolella, Michael V Rothberg, David E Root, Cory M Johannessen, Laxmi Parida, Gad A Getz, Francisca Vazquez, John G Doench, Mahdi Zamanighomi, William R Sellers
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nature genetics 53 (12) (2021)
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G Doench, Lynda Bennett, Beth Levine
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proceedings of the National Academy of Sciences of the United States of America 118 (5) (2021)
Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadão, Lowiese Desmarets, Yves Rouillé, Marine Tauziet, Mary Arnaud-Arnould, Donatella Giovannini, Yenarae Lee, Peter DeWeirdt, Mudra Hegde, Francisco Garcia de Gracia, Joe McKellar, Mélanie Wencker, Jean Dubuisson, Sandrine Belouzard, Olivier Moncorgé, John G Doench, Caroline Goujon
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses. bioRxiv : the preprint server for biology (2021)
Gabriel K Griffin, Jingyi Wu, Arvin Iracheta-Vellve, James C Patti, Jeffrey Hsu, Thomas Davis, Deborah Dele-Oni, Peter P Du, Aya G Halawi, Jeffrey J Ishizuka, Sarah Y Kim, Susan Klaeger, Nelson H Knudsen, Brian C Miller, Tung H Nguyen, Kira E Olander, Malvina Papanastasiou, Suzanna Rachimi, Emily J Robitschek, Emily M Schneider, Mitchell D Yeary, Margaret D Zimmer, Jacob D Jaffe, Steven A Carr, John G Doench, W Nicholas Haining, Kathleen B Yates, Robert T Manguso, Bradley E Bernstein
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Nature 595 (7866) (2021)
Vidyasagar Koduri, Leslie Duplaquet, Benjamin L Lampson, Adam C Wang, Amin H Sabet, Mette Ishoey, Joshiawa Paulk, Mingxing Teng, Isaac S Harris, Jennifer E Endress, Xiaoxi Liu, Ethan Dasilva, Joao A Paulo, Kimberly J Briggs, John G Doench, Christopher J Ott, Tinghu Zhang, Katherine Aleisha Donovan, Eric S Fischer, Steven P Gygi, Nathanael S Gray, James E Bradner, Jeffrey A Medin, Sara J Buhrlage, Matthew G Oser, William G Kaelin
Targeting oncoproteins with a positive selection assay for protein degraders. Science advances 7 (6) (2021)
Jin Wei, Mia Madel Alfajaro, Ruth E Hanna, Peter C DeWeirdt, Madison S Strine, William J Lu-Culligan, Shang-Min Zhang, Vincent R Graziano, Cameron O Schmitz, Jennifer S Chen, Madeleine C Mankowski, Renata B Filler, Victor Gasque, Fernando de Miguel, Huacui Chen, Kasopefoluwa Oguntuyo, Laura Abriola, Yulia V Surovtseva, Robert C Orchard, Benhur Lee, Brett Lindenbach, Katerina Politi, David van Dijk, Matthew D Simon, Qin Yan, John G Doench, Craig B Wilen
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. bioRxiv : the preprint server for biology (2020)
Yilong Zou, Haoxin Li, Emily T Graham, Amy A Deik, John K Eaton, Wenyu Wang, Gerardo Sandoval-Gomez, Andrew T Chan, John G Doench, Stuart L Schreiber
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nature chemical biology 16 (3) (2020)
Oana M Enache, Veronica Rendo, Mai Abdusamad, Daniel Lam, Desiree Davison, Sangita Pal, Naomi Currimjee, Julian Hess, Sasha Pantel, Anwesha Nag, Aaron R Thorner, John G Doench, Francisca Vazquez, Rameen Beroukhim, Todd R Golub, Uri Ben-David
Cas9 activates the p53 pathway and selects for p53-inactivating mutations. Nature genetics 52 (7) (2020)
Bo Li, Sara Clohisey Hendry, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D Schweitzer, Paul Hoover, Nicholas J Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H Dockrell, John G Doench, John Kenneth Baillie, Nir Hacohen
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nature communications 11 (1) (2020)

John G Doench.css-eqlu8i{font-size:small;padding-left:4px;} (John Doench)

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John G Doench (John Doench)