Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care.
Edwin CuppenOlivier ElementoRichard RosenquistSvetlana NikicMaarten IJzermanIsabelle Durand ZaleskiGeert FrederixLars-Åke LevinCharles G MullighanReinhard ButtnerTrevor J PughSean M GrimmondCarlos CaldasFabrice AndreIlse CustersElias CampoHans van SnellenbergAnna SchuhHidewaki NakagawaChristof von KalleTorsten HaferlachStefan FröhlingVaidehi JobanputraPublished in: JCO precision oncology (2022)
WGTS is an appropriate comprehensive clinical test for many tumor types and can replace multiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number of clinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave the way for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosis and treatment for patients with cancer.