MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.
Matthew L HemmingMorgan R BensonMichael A LoycanoJustin A AndersonJessica L AndersenMadeleine L TaddeiAndrei V KrivtsovBrandon J AubreyJevon A CutlerCharles HattonEwa SicinskaScott A ArmstrongPublished in: Cancer discovery (2022)
Although many malignancies rely on oncogene amplification, GIST instead depends upon epigenetic regulation of KIT and other essential genes. Utilizing genome-scale CRISPR dependency screens, we identified complementary chromatin-modifying complexes essential to GIST and characterize the consequences of their disruption, elucidating a novel therapeutic approach to this disease. This article is highlighted in the In This Issue feature, p. 1599.