Scott A Armstrong

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 23

Top Topics

Acute Myeloid Leukemia

Gene Expression

Top Venues

Cancer discovery

Science advances

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Michael R Waarts, Shoron Mowla, Meaghan Boileau, Anthony R Martinez Benitez, Junya Sango, Maya Bagish, Ines Fernandez-Maestre, Yufan Shan, Shira E Eisman, Young C Park, Matthew Wereski, Isabelle Csete, Kavi O'Connor, Angelica C Romero-Vega, Linde A Miles, Wenbin Xiao, Xiaodi Wu, Richard P Koche, Scott A Armstrong, Alan H Shih, Eirini P Papapetrou, Jason M Butler, Sheng F Cai, Robert L Bowman, Ross L Levine
CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype Specific Vulnerability in IDH2- and TET2-Mutant Cells. Cancer discovery (2024)
Michael R Waarts, Shoron Mowla, Meaghan Boileau, Anthony R Martinez Benitez, Junya Sango, Maya Bagish, Ines Fernandez-Maestre, Yufan Shan, Shira E Eisman, Young C Park, Matthew Wereski, Isabelle Csete, Kavi O'Connor, Angelica C Romero-Vega, Linde A Miles, Wenbin Xiao, Xiaodi Wu, Richard P Koche, Scott A Armstrong, Alan H Shih, Eirini P Papapetrou, Jason M Butler, Sheng F Cai, Robert L Bowman, Ross L Levine
CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype Specific Vulnerability in IDH2- and TET2-Mutant Cells. Cancer discovery (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Michael R Waarts, Shoron Mowla, Meaghan Boileau, Anthony R Martinez Benitez, Junya Sango, Maya Bagish, Ines Fernandez-Maestre, Yufan Shan, Shira E Eisman, Young C Park, Matthew Wereski, Isabelle Csete, Kavi O'Connor, Angelica C Romero-Vega, Linde A Miles, Wenbin Xiao, Xiaodi Wu, Richard P Koche, Scott A Armstrong, Alan H Shih, Eirini P Papapetrou, Jason M Butler, Sheng F Cai, Robert L Bowman, Ross L Levine
CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype Specific Vulnerability in IDH2- and TET2-Mutant Cells. Cancer discovery (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Changyu Zhu, Yadira M Soto-Feliciano, John P Morris, Chun-Hao Huang, Richard P Koche, Yu-Jui Ho, Ana Banito, Chun-Wei David Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A Armstrong, C David Allis, Darjus F Tschaharganeh, Scott W Lowe
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. eLife 12 (2023)
Leslie Duplaquet, Yixiang Li, Matthew A Booker, Yingtian Xie, Sarah Naomi Olsen, Radhika A Patel, Deli Hong, Charles Hatton, Thomas Denize, Emily Walton, Yasmin N Laimon, Rong Li, Yijia Jiang, Roderick T Bronson, Jackson Southard, Shuqiang Li, Sabina Signoretti, Xintao Qiu, Paloma Cejas, Scott A Armstrong, Henry W Long, Michael Y Tolstorukov, Michael C Haffner, Matthew G Oser
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. Nature cell biology (2023)
Ghayas C Issa, Ibrahim Aldoss, John F Dipersio, Branko Cuglievan, Richard M Stone, Martha Arellano, Michael J Thirman, Manish R Patel, David S Dickens, Shalini Shenoy, Neerav Shukla, Hagop M Kantarjian, Scott A Armstrong, Florian Perner, Jennifer A Perry, Galit Rosen, Rebecca G Bagley, Michael L Meyers, Peter Ordentlich, Yu Gu, Vinit Kumar, Steven Smith, Gerard M McGeehan, Eytan M Stein
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. Nature (2023)
Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed S Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz, Jarrod A Marto, Danilo Pellin, Daniel E Bauer, Scott A Armstrong, Pietro Genovese
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia. Nature (2023)
Florian Perner, Eytan M Stein, Daniela V Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A Gamlen, Aaron James Stonestrom, Sonali Persaud, Elizabeth T Ener, Jevon A Cutler, John G Doench, Gerard M McGeehan, Andrea Volkamer, John D Chodera, Radosław P Nowak, Eric S Fischer, Ross L Levine, Scott A Armstrong, Sheng F Cai
MEN1 mutations mediate clinical resistance to menin inhibition. Nature (2023)
Brandon J Aubrey, Jevon A Cutler, Wallace Bourgeois, Katherine A Donovan, Shengqing Gu, Charles Hatton, Sarah Perlee, Florian Perner, Homa Rahnamoun, Alexandra C P Theall, Jill A Henrich, Qian Zhu, Radosław P Nowak, Young Joon Kim, Salma Parvin, Anjali Cremer, Sarah Naomi Olsen, Nicholas A Eleuteri, Yana Pikman, Gerard M McGeehan, Kimberly Stegmaier, Anthony G Letai, Eric S Fischer, X Shirley Liu, Scott A Armstrong
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nature cancer 3 (5) (2022)
Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric M Wong, Charles Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J C Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei David Chen, Scott A Armstrong
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia. Cancer discovery (2022)
Yadira M Soto-Feliciano, Francisco J Sánchez Rivera, Florian Perner, Douglas W Barrows, Edward R Kastenhuber, Yu-Jui Ho, Thomas S Carroll, Yijun Xiong, Disha Anand, Alexey A Soshnev, Leah A Gates, Mary Clare Beytagh, David Cheon, Shengqing Stan Gu, X Shirley Liu, Andrei V Krivtsov, Maximiliano Meneses, Elisa De Stanchina, Richard M Stone, Scott A Armstrong, Scott W Lowe, C David Allis
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Cancer discovery (2022)
Wilfred Leung, Matthew R Teater, Ceyda Durmaz, Cem Meydan, Alexandra G Chivu, Amy Chadburn, Edward J Rice, Ashlesha Muley, Jeannie M Camarillo, Jaison Arivalagan, Ziyi Li, Christopher R Flowers, Michael P Snyder, Charles G Danko, Marcin Imielinski, Sandeep S Dave, Scott A Armstrong, Christopher E Mason, Ari M Melnick
SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. Cancer discovery 12 (7) (2022)
Matthew L Hemming, Morgan R Benson, Michael A Loycano, Justin A Anderson, Jessica L Andersen, Madeleine L Taddei, Andrei V Krivtsov, Brandon J Aubrey, Jevon A Cutler, Charles Hatton, Ewa Sicinska, Scott A Armstrong
MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Cancer discovery 12 (7) (2022)
Florian Perner, Tina M Schnoeder, Yijun Xiong, Ashok Kumar Jayavelu, Nomusa Mashamba, Nuria Tubio Santamaria, Nicolas Huber, Kristina Todorova, Charles Hatton, Birgit Perner, Theresa Eifert, Ciara Murphy, Maximilian Hartmann, Jessica I Hoell, Nicolas Schröder, Sabine Brandt, Andreas Hochhaus, Peter R Mertens, Matthias Mann, Scott A Armstrong, Anna Mandinova, Florian H Heidel
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML. Leukemia (2021)
Lu Yang, Anthony K N Chan, Kazuya Miyashita, Christopher D Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A Armstrong, Chun-Wei David Chen
High-resolution characterization of gene function using single-cell CRISPR tiling screen. Nature communications 12 (1) (2021)
Steffen Boettcher, Peter Grant Miller, Rohan Sharma, Marie McConkey, Matthew Joseph Leventhal, Andrei V Krivtsov, Andrew O Giacomelli, Waihay J Wong, Jesi Kim, Sherry Chao, Kari J Kurppa, Xiaoping Yang, Kirsten Milenkowic, Frederica Piccioni, David E Root, Frank G Rücker, Yael Flamand, Donna S Neuberg, R Coleman Lindsley, Pasi A Jänne, William C Hahn, Tyler Jacks, Hartmut Döhner, Scott A Armstrong, Benjamin L Ebert
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science (New York, N.Y.) 365 (6453) (2020)
Hannah J Uckelmann, Stephanie M Kim, Eric M Wong, Charles Hatton, Hugh Giovinazzo, Jayant Y Gadrey, Andrei V Krivtsov, Frank G Rücker, Konstanze Döhner, Gerard M McGeehan, Ross L Levine, Lars Bullinger, George S Vassiliou, Scott A Armstrong
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia. Science (New York, N.Y.) 367 (6477) (2020)
Gerard L Brien, Kimberly Stegmaier, Scott A Armstrong
Targeting chromatin complexes in fusion protein-driven malignancies. Nature reviews. Cancer 19 (5) (2019)
Gerard L Brien, David Remillard, Junwei Shi, Matthew L Hemming, Jonathon Chabon, Kieran Wynne, Eugène T Dillon, Gerard Cagney, Guido Van Mierlo, Marijke P Baltissen, Michiel Vermeulen, Jun Qi, Stefan Fröhling, Nathanael S Gray, James E Bradner, Christopher R Vakoc, Scott A Armstrong
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. eLife 7 (2018)
Eneda Toska, Hatice U Osmanbeyoglu, Hatice Ulku Osmanbeyoglu, Carmen Chan, Ronald C Hendrickson, Moshe Elkabets, Maura N Dickler, Maurizio Scaltriti, Christina S Leslie, Scott A Armstrong, Jose Baselga
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science (New York, N.Y.) 355 (6331) (2017)