The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response.
Jacob E BerchuckElio AdibSarah Abou AlaiwiAmit K DashJin Na ShinDallin LowderCollin McCollPatricia D CastroRyan CarelliElisa BenedettiJenny DengMatthew RobertsonSylvan C BacaConnor BellHeather M McClureAmin H NassarMatthew P DavidsohnGitanjali LakshminarayananKinza RizwanDarlene G SkapuraSandra L GrimmChristel M DavisErik A EhliKaitlin M KelleherJi-Heui SeoNicholas MitsiadesCristian CoarfaMark M PomerantzMassimo LodaMichael IttmannMatthew L FreedmanSalma KaocharPublished in: Cancer research (2022)
With immunotherapies and inhibitors of metabolic enzymes in clinical development, the altered lipid metabolism and immune response in African-American men provides potential therapeutic opportunities to attenuate racial disparities in prostate cancer.