New trends in cellular therapy.
Hideyuki OkanoDouglas SippPublished in: Development (Cambridge, England) (2020)
Regenerative therapies, including both gene and cellular therapies, aim to induce regeneration of cells, tissues and organs and restore their functions. In this short Spotlight, we summarize the latest advances in cellular therapies using pluripotent stem cells (PSCs), highlighting the current status of clinical trials using induced (i)PSC-derived cells. We also discuss the different cellular products that might be used in clinical studies, and consider safety issues and other challenges in iPSC-based cell therapy.
Keyphrases
- cell therapy
- induced apoptosis
- stem cells
- clinical trial
- cell cycle arrest
- mesenchymal stem cells
- current status
- gene expression
- endoplasmic reticulum stress
- pluripotent stem cells
- randomized controlled trial
- copy number
- signaling pathway
- oxidative stress
- dna methylation
- drug induced
- cell proliferation
- transcription factor
- study protocol
- phase ii
- wound healing
- induced pluripotent stem cells
- genome wide analysis