GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favorable disease course in ulcerative colitis (UC).

Katya E SosnovskiTzipi BraunAmnon AmirDanielle MoshelMarina BenShoshanKelli L VanDussen Nina LevharHaya Abbas-EgbariyaKatia BeiderRakefet Ben-YishaySyed Asad AliSean R MooreSubra KugathasanIfat AbramovichEfrat Glick SaarBatya WeissIris BarshackEyal GottliebTamar GeigerShomron Ben-HorinIgor UlitskyJeffrey S HyamsLee A Denson Yael Haberman

Published in: Journal of Crohn's & colitis (2023)

GATA6-AS1 levels are reduced in UC, CD, and celiac, and in more severe UC forms. We highlight GATA6-AS1 as a target regulating epithelial mitochondrial functions, potentially through controlling TGM2 levels.

Keyphrases

oxidative stress
transcription factor
ulcerative colitis
poor prognosis
early onset
drug induced
celiac disease