GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favorable disease course in ulcerative colitis (UC).
Katya E SosnovskiTzipi BraunAmnon AmirDanielle MoshelMarina BenShoshanKelli L VanDussenNina LevharHaya Abbas-EgbariyaKatia BeiderRakefet Ben-YishaySyed Asad AliSean R MooreSubra KugathasanIfat AbramovichEfrat Glick SaarBatya WeissIris BarshackEyal GottliebTamar GeigerShomron Ben-HorinIgor UlitskyJeffrey S HyamsLee A DensonYael HabermanPublished in: Journal of Crohn's & colitis (2023)
GATA6-AS1 levels are reduced in UC, CD, and celiac, and in more severe UC forms. We highlight GATA6-AS1 as a target regulating epithelial mitochondrial functions, potentially through controlling TGM2 levels.