Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.
Keyphrases
- brain injury
- subarachnoid hemorrhage
- cell death
- cerebral ischemia
- poor prognosis
- cell cycle arrest
- oxidative stress
- cerebral blood flow
- systematic review
- intensive care unit
- randomized controlled trial
- dna damage
- neuropathic pain
- spinal cord
- white matter
- multiple sclerosis
- fatty acid
- ischemia reperfusion injury
- resting state
- mechanical ventilation
- functional connectivity
- cell proliferation
- aortic dissection
- cognitive impairment
- current status
- signaling pathway
- acute respiratory distress syndrome
- heat stress