Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients.
Andi LiuYulin DaiEmily F MendezRuifeng HuGabriel R FriesKatherine E NajeraShan JiangThomas D MeyerLaura StertzPeilin JiaConsuelo Walss-BassZhong-Ming ZhaoPublished in: The international journal of neuropsychopharmacology (2022)
Our integrative analysis of multi-omics data in OUD postmortem brain samples suggested complex gene regulatory mechanisms involved in OUD-associated expression patterns. Candidate genes and their upstream regulators revealed in astrocyte, and glial cells could provide new insights into OUD treatment development.
Keyphrases
- dna methylation
- gene expression
- genome wide
- end stage renal disease
- ejection fraction
- white matter
- poor prognosis
- newly diagnosed
- induced apoptosis
- single cell
- chronic kidney disease
- peritoneal dialysis
- cell cycle arrest
- copy number
- transcription factor
- big data
- prognostic factors
- binding protein
- cerebral ischemia
- oxidative stress
- signaling pathway
- multiple sclerosis
- machine learning
- blood brain barrier
- combination therapy
- subarachnoid hemorrhage
- cell proliferation