Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49 -Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans .
Zhong-Qin WuYu XiaoFang ZhouJiaxu ChenXinming ChenAixiang HouYuanliang WangZongjun LiPublished in: Molecules (Basel, Switzerland) (2022)
Pasteurized Akkermansia muciniphila (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using Caenorhabditis elegans . The results showed that p-AKK increased the healthy lifespan of nematodes and helped maintain exercise ability in aging, suggesting a potential increase in energy expenditure. The overall fat deposition and triglyceride level were significantly decreased and the p-AKK anti-oxidative stress helped to regulate fatty acid composition. Additionally, the transcriptome results showed that p-AKK increased the expression of lipo-hydrolase and fatty acid β-oxidation-related genes, including lipl-4 , nhr-49 , acs-2 and acdh-8 , while it decreased the expression of fat synthesis-related genes, including fat-7 , elo-2 and men-1 . These results partially explain the mechanisms underlying the fact that p-AKK decreases fat accumulation of C. elegans via nhr-49 / acs-2 -mediated signaling involved in fatty acid β-oxidation and synthesis.
Keyphrases
- fatty acid
- adipose tissue
- oxidative stress
- poor prognosis
- signaling pathway
- acute coronary syndrome
- type diabetes
- metabolic syndrome
- physical activity
- hydrogen peroxide
- gene expression
- human milk
- nitric oxide
- dna damage
- high intensity
- risk assessment
- rna seq
- epithelial mesenchymal transition
- dna methylation
- pi k akt
- climate change
- skeletal muscle
- body composition
- resistance training