CPT: pharmacometrics & systems pharmacology

Keyphrases

Publications

2023

Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao
Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae. CPT: pharmacometrics & systems pharmacology (2023)
Miyoung Yoon, Andrew Babiskin, Meng Hu, Fang Wu, Sam G Raney, Lanyan Fang, Liang Zhao
Increasing impact of quantitative methods and modeling in establishment of bioequivalence and characterization of drug delivery. CPT: pharmacometrics & systems pharmacology (2023)
Ahmed Elmokadem, Yi Zhang, Timothy Knab, Eric Jordie, William R Gillespie
Bayesian PBPK Modeling using R/Stan/Torsten and Julia/SciML/Turing.jl. CPT: pharmacometrics & systems pharmacology (2023)
Estelle Yau, Andres M Olivares-Morales, Kayode Ogungbenro, Leon Aarons, Michael Gertz
Investigation of simplified physiologically-based pharmacokinetic models in rat and human. CPT: pharmacometrics & systems pharmacology (2023)
Jennifer E Hibma, Priya Jayachandran, Srividya Neelakantan, Lutz O Harnisch
Disease progression modeling of the North Star Ambulatory Assessment (NSAA) for Duchenne Muscular Dystrophy (DMD). CPT: pharmacometrics & systems pharmacology (2023)
Andrew Babiskin, Fang Wu, Youssef Mousa, Ming-Liang Tan, Eleftheria Tsakalozou, Ross L Walenga, Miyoung Yoon, Sam G Raney, James E Polli, Anna Schwendeman, Vishalakshi Krishnan, Lanyan Fang, Liang Zhao
Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches: A Workshop Overview. CPT: pharmacometrics & systems pharmacology (2023)
Hinke Siebinga, Bastiaan M Privé, Steffie M B Peters, James Nagarajah, Thomas P C Dorlo, Alwin D R Huitema, Berlinda Jantina de Wit-van der Veen, Jeroen J M A Hendrikx
Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of 177 Lu-PSMA-617 in prostate cancer patients. CPT: pharmacometrics & systems pharmacology (2023)
Yuqing Gong, Peijue Zhang, Miyoung Yoon, Hao Zhu, Ameya Kohojkar, Andrew C Hooker, Murray P Ducharme, Jogarao V S Gobburu, Géraldine Cellière, Parmesh Gajjar, Bing V Li, Raja Velagapudi, Yu Chung Tsang, Anna Schwendeman, James E Polli, Lanyan Fang, Robert Lionberger, Liang Zhao
Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop. CPT: pharmacometrics & systems pharmacology (2023)

volume 12, number 1, 2023

volume 12, number 11, 2023

Sophie Marolleau, Alice Mogenet, Clara Boeri, Mourad Hamimed, Joseph Ciccolini, Laurent Greillier
Killing a fly with a sledgehammer: Atezolizumab exposure in real-world lung cancer patients. CPT: pharmacometrics & systems pharmacology 12 (11) (2023)

volume 12, number 2, 2023

Malidi Ahamadi, Johannes Kast, Po-Wei Chen, Xiaojun Huang, Sandeep Dutta, Vijay V Upreti
Oncolytic viral kinetics mechanistic modeling of Talimogene Laherparepvec (T-VEC) a first-in-class oncolytic viral therapy in patients with advanced melanoma. CPT: pharmacometrics & systems pharmacology 12 (2) (2023)
Malidi Ahamadi, Johannes Kast, Po-Wei Chen, Xiaojun Huang, Sandeep Dutta, Vijay V Upreti
Oncolytic viral kinetics mechanistic modeling of Talimogene Laherparepvec (T-VEC) a first-in-class oncolytic viral therapy in patients with advanced melanoma. CPT: pharmacometrics & systems pharmacology 12 (2) (2023)
Malidi Ahamadi, Johannes Kast, Po-Wei Chen, Xiaojun Huang, Sandeep Dutta, Vijay V Upreti
Oncolytic viral kinetics mechanistic modeling of Talimogene Laherparepvec (T-VEC) a first-in-class oncolytic viral therapy in patients with advanced melanoma. CPT: pharmacometrics & systems pharmacology 12 (2) (2023)

volume 12, number 3, 2023

Ahmed Elmokadem, Yi Zhang, Timothy Knab, Eric Jordie, William R Gillespie
Bayesian PBPK modeling using R/Stan/Torsten and Julia/SciML/Turing.Jl. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Martin Johnson, Mishal Patel, Alex Phipps, Mihaela van der Schaar, Dave Boulton, Megan Gibbs
The potential and pitfalls of artificial intelligence in clinical pharmacology. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Lars Kuepfer, Georg Fuellen, Thomas Stahnke
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao
Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Isabelle H S Kuan, Daniel F B Wright, Stephen B Duffull
The influence of flip-flop in population pharmacokinetic analyses. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Cindy H T Yeung, Jessica L Beers, Klarissa D Jackson, Andrea N Edginton
Verifying in vitro-determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically-based pharmacokinetic modeling. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Henrik Cordes, Hermann Rapp
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Estelle Yau, Andres M Olivares-Morales, Kayode Ogungbenro, Leon Aarons, Michael Gertz
Investigation of simplified physiologically-based pharmacokinetic models in rat and human. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Jennifer E Hibma, Priya Jayachandran, Srividya Neelakantan, Lutz O Harnisch
Disease progression modeling of the North Star Ambulatory Assessment for Duchenne Muscular Dystrophy. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Henrik Cordes, Hermann Rapp
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Estelle Yau, Michael Gertz, Kayode Ogungbenro, Leon Aarons, Andres M Olivares-Morales
A "middle-out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Estelle Yau, Michael Gertz, Kayode Ogungbenro, Leon Aarons, Andres M Olivares-Morales
A "middle-out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Lars Kuepfer, Georg Fuellen, Thomas Stahnke
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Conor J O'Hanlon, Nick H G Holford, Anita Sumpter, Hesham S Al-Sallami
Consistent methods for fat-free mass, creatinine clearance, and glomerular filtration rate to describe renal function from neonates to adults. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Yan Ji, Kumpal Madrasi, Deborah A Knee, Lore M Gruenbaum, Joshua F Apgar, John M Burke, Bruce Gomes
Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao
Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Jennifer E Hibma, Priya Jayachandran, Srividya Neelakantan, Lutz O Harnisch
Disease progression modeling of the North Star Ambulatory Assessment for Duchenne Muscular Dystrophy. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Ahmed Elmokadem, Yi Zhang, Timothy Knab, Eric Jordie, William R Gillespie
Bayesian PBPK modeling using R/Stan/Torsten and Julia/SciML/Turing.Jl. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Anshul Saini, Annabelle Ballesta, James M Gallo
Cell state-directed therapy - epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Yan Ji, Kumpal Madrasi, Deborah A Knee, Lore M Gruenbaum, Joshua F Apgar, John M Burke, Bruce Gomes
Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Conor J O'Hanlon, Nick H G Holford, Anita Sumpter, Hesham S Al-Sallami
Consistent methods for fat-free mass, creatinine clearance, and glomerular filtration rate to describe renal function from neonates to adults. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Anshul Saini, Annabelle Ballesta, James M Gallo
Cell state-directed therapy - epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Martin Johnson, Mishal Patel, Alex Phipps, Mihaela van der Schaar, Dave Boulton, Megan Gibbs
The potential and pitfalls of artificial intelligence in clinical pharmacology. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Estelle Yau, Andres M Olivares-Morales, Kayode Ogungbenro, Leon Aarons, Michael Gertz
Investigation of simplified physiologically-based pharmacokinetic models in rat and human. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Cindy H T Yeung, Jessica L Beers, Klarissa D Jackson, Andrea N Edginton
Verifying in vitro-determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically-based pharmacokinetic modeling. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Isabelle H S Kuan, Daniel F B Wright, Stephen B Duffull
The influence of flip-flop in population pharmacokinetic analyses. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)
Isabelle H S Kuan, Daniel F B Wright, Stephen B Duffull
The influence of flip-flop in population pharmacokinetic analyses. CPT: pharmacometrics & systems pharmacology 12 (3) (2023)

volume 12, number 5, 2023

volume 12, number 7, 2023

Richard J Matthews, David Hollinshead, Daniel Morrison, Piet H van der Graaf, Andrzej M Kierzek
QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation. CPT: pharmacometrics & systems pharmacology 12 (7) (2023)
Stephan Schmidt, Valvanera Vozmediano, Rodrigo Cristofoletti, Sarah Kim, Zhoumeng Lin, Natália Valadares de Moraes, Francine Azeredo, Brian Cicali, Hans Leuenberger, Joshua D Brown, Jin Yan Jin, Cynthia J Musante, Stacey Tannenbaum, Yaning Wang
Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians. CPT: pharmacometrics & systems pharmacology 12 (7) (2023)