Bioorganic & medicinal chemistry

Keyphrases

Publications

volume 113, 2024

Lukas Kerti, Vladimir Frecer
Design of inhibitors of SARS-CoV-2 papain-like protease deriving from GRL0617: Structure-activity relationships. Bioorganic & medicinal chemistry 113 (2024)
Adchata Konsue, Thomanai Lamtha, Duangkamol Gleeson, Donald J L Jones, Robert G Britton, James D Pickering, Kiattawee Choowongkomon, M Paul Gleeson
Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer. Bioorganic & medicinal chemistry 113 (2024)
Liuyanlin Zhang, Houjin Zhang
Recent advances of affibody molecules in biomedical applications. Bioorganic & medicinal chemistry 113 (2024)
Md Kamal Hossain, Majid Davidson, Jack Feehan, John M Matsoukas, Kulmira Nurgali, Vasso Apostolopoulos
A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose. Bioorganic & medicinal chemistry 113 (2024)
Jiexin Li, Xiansong Wang, Hongsheng Wang
RNA modifications in long non-coding RNAs and their implications in cancer biology. Bioorganic & medicinal chemistry 113 (2024)
Prachi Sharma, Sunil Sharma, Yogesh Yadav, Paritosh Shukla, Ram Sagar
Current pharmacophore based approaches for the development of new anti-Alzheimer's agents. Bioorganic & medicinal chemistry 113 (2024)
Yixuan Lin, Riichi Hashimoto, Tsung-Che Chang, Katsunori Tanaka
Synthesis of phenanthridine derivatives by a water-compatible gold-catalyzed hydroamination. Bioorganic & medicinal chemistry 113 (2024)
Yindi Zhang, Yueping Jiang, Kaiqi Shang, Chengyu Ge, Jing Fang, Shao Liu
Updated pharmaceutical progress on plant antibiotic rhein and its analogs: Bioactivities, structure-activity relationships and future perspectives. Bioorganic & medicinal chemistry 113 (2024)
Ludovic Le Saux, Ferid Haddad, Jean-François Gestin, Romain Eychenne, François Guérard
Sydnone-based prosthetic groups for radioiodination. Bioorganic & medicinal chemistry 113 (2024)
Linjie Zhang, Zixuan Yu, Yaojin Zhu, Chenxi Zhang, Li Su, Shipeng He, Heng Yin, Yongsheng Yu, Minyu Zhu
Pegylation enhances the anti-osteoporosis activity of acacetin in both ovariectomized and LPS-stimulated mice. Bioorganic & medicinal chemistry 113 (2024)
Chris La Rosa, Pankaj Sharma, M Junaid Dar, Yiru Jin, Lingli Qin, Anuradha Roy, Allie Kendall, Meng Wu, Zhihong Lin, Dmitriy Uchenik, Junan Li, Somrita Basu, Samrat Moitra, Kai Zhang, Michael Zhuo Wang, Karl A Werbovetz
N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors. Bioorganic & medicinal chemistry 113 (2024)

volume 112, 2024

Ye Tian, Xiaofang He, Ruping Li, Yanxin Wu, Qiang Ren, Yusen Hou
Recent advances in the treatment of gout with NLRP3 inflammasome inhibitors. Bioorganic & medicinal chemistry 112 (2024)
Kewei Yi, Peng Wang, Chunmao He
Facile incorporation of non-canonical heme ligands in myoglobin through chemical protein synthesis. Bioorganic & medicinal chemistry 112 (2024)
Minna Rahnasto-Rilla, Tatu Puumalainen, Vilma Karttunen, Santosh Kumar Adla, Maija Lahtela-Kakkonen
Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines. Bioorganic & medicinal chemistry 112 (2024)
Benjamin Ayodipupo Babalola, Lekhnath Sharma, Olanike Olowokere, Monika Malik, Oreoluwa Folajimi
Advancing drug discovery: Thiadiazole derivatives as multifaceted agents in medicinal chemistry and pharmacology. Bioorganic & medicinal chemistry 112 (2024)
Yuhei Horai, Naoki Suda, Shinsuke Uchihashi, Mayako Katakuse, Tomomi Shigeno, Takashige Hirano, Junichi Takahara, Tomoyuki Fujita, Yohei Mukoyama, Yuji Haga
A novel 7-phenoxy-benzimidazole derivative as a potent and orally available BRD4 inhibitor for the treatment of melanoma. Bioorganic & medicinal chemistry 112 (2024)
Huajun Lei, Wei Xiong, Ming Li, Qianqian Qi, Xingyu Liu, Shaoru Wang, Tian Tian, Xiang Zhou
Enhanced control of RNA modification and CRISPR-Cas activity through redox-triggered disulfide cleavage. Bioorganic & medicinal chemistry 112 (2024)
Samuele Maramai, Mario Saletti, Marco Paolino, Germano Giuliani, Jessica Cazzola, Paolo Spaiardi, Francesca Talpo, Maria Frosini, Alice Pifferi, Marco Ballarotto, Andrea Carotti, Federica Poggialini, Chiara Vagaggini, Elena Dreassi, Gianluca Giorgi, Giulio Dondio, Andrea Cappelli, Gerardo Rosario Biella, Maurizio Anzini
Novel multitarget directed ligands inspired by riluzole: A serendipitous synthesis of substituted benzo[b][1,4]thiazepines potentially useful as neuroprotective agents. Bioorganic & medicinal chemistry 112 (2024)
Jean-Philippe Surivet, Melanie Kessler, Catherine Vaillant, Hamed Aissaoui, Olivier Bezençon, Louise Busch, Manon Kiry, Urs Lüthi, Nicolas Marck, Florence Masse, Jens-Uwe Peters, Catherine Sweatman, Aude Weigel, Christopher Kohl
Discovery, synthesis and SAR of 2-acyl-1-biarylmethyl pyrazolidines, dual orexin receptor antagonists designed as fast and short-acting sleeping drugs. Bioorganic & medicinal chemistry 112 (2024)
Rajibul Islam, Khor Poh Yen, Nur Najihah 'Izzati Mat Rani, Md Selim Hossain
Recent advancement in developing small molecular inhibitors targeting key kinase pathways against triple-negative breast cancer. Bioorganic & medicinal chemistry 112 (2024)
Minhajul Arfeen, Ashish Srivastava, Noopur Srivastava, Riaz A Khan, Suliman A Almahmoud, Hamdoon A Mohammed
Design, classification, and adverse effects of NSAIDs: A review on recent advancements. Bioorganic & medicinal chemistry 112 (2024)
De-Jie Zhang, Zi-Qi Yuan, Yan-Xin Yue, Min Zhang, Wen-Juan Wu, Cai-Guang Yang, Wen-Wei Qiu
Synthesis and antibacterial activities of heterocyclic ring-fused 20(S)-protopanaxadiol derivatives. Bioorganic & medicinal chemistry 112 (2024)
Xiong-Fei Luo, Han Zhou, Peng Deng, Shao-Yong Zhang, Yi-Rong Wang, Yan-Yan Ding, Guang-Han Wang, Zhi-Jun Zhang, Zheng-Rong Wu, Ying-Qian Liu
Current development and structure-activity relationship study of berberine derivatives. Bioorganic & medicinal chemistry 112 (2024)
Qingbin Cui, Wenwen Ding, Bingling Luo, Wenhua Lu, Peng Huang, Shijun Wen
Novel gold-based complex GC7 suppresses cancer cell proliferation via impacting energy metabolism mediated by mitochondria. Bioorganic & medicinal chemistry 112 (2024)
Alex Ann, Steven Truong, Jiwani Peters, David R Mootoo
Synthesis of alpha-Gal C-disaccharides. Bioorganic & medicinal chemistry 112 (2024)
Charles D Waters, Evan Carlyle, Viviana Smart, Apurv Rege, Charles J Bieberich, Katherine L Seley-Radtke
Proximal fleximer analogues of 2'-deoxy-2'-fluoro-2'-methyl purine nucleos(t)ides: Synthesis and preliminary pharmacokinetic and antiviral evaluation. Bioorganic & medicinal chemistry 112 (2024)
Debsankar Sahoo, Priya Deb, Tamal Basu, Srishti Bardhan, Sayan Patra, Pradip K Sukul
Advancements in platinum-based anticancer drug development: A comprehensive review of strategies, discoveries, and future perspectives. Bioorganic & medicinal chemistry 112 (2024)
Marcus J C Long, Yimon Aye
Let's get biophysical - How to get your favorite protein's digits. Bioorganic & medicinal chemistry 112 (2024)
Duc V H Tran, Thanh K Pham, Young-Woo Kim
Amine-bearing hydrocarbon cross-links: Tailoring helix stability, hydrophilicity, and synthetic adaptability in peptides. Bioorganic & medicinal chemistry 112 (2024)
Sushree Arpitabala Yadav, V Kusum Vats, Rohit Sharma, Nitish Chauhan, Mahesh Subramanian, Amit Das, Drishty Satpati
177 Lu-labeling of nuclear localization sequence (NLS)-grafted HER2-receptor affine peptide. Bioorganic & medicinal chemistry 112 (2024)
Soumik De, Raghaba Sahu, Shubhendu Palei, Laxmi Narayan Nanda
Synthesis, SAR, and application of JQ1 analogs as PROTACs for cancer therapy. Bioorganic & medicinal chemistry 112 (2024)
Luxia Liang, Ze Zhang, Qidong You, Xiaoke Guo
Recent advances in the design of small molecular drugs with acrylamides covalent warheads. Bioorganic & medicinal chemistry 112 (2024)
Yi Du, Xiya Chen, Weiji Chen, Gang Chen, Xiaoling Cheng, Hailing Wang, Ling Guo, Chenyang Li, Dahong Yao
Design, synthesis and biological evaluation of a novel PAK1 degrader for the treatment of triple negative breast cancer. Bioorganic & medicinal chemistry 112 (2024)
Jingyang Sun, Seojeong Kim, Seojeong Park, Seohui Hwang, Naeun Sheen, Soobin Kim, Youngjoo Kwon, Jae-Sang Ryu
Exploring novel A 2A AR antagonists: Design, synthesis, and evaluation of 2,6,9-trisubstituted purine derivatives as promising antifibrotic agents. Bioorganic & medicinal chemistry 112 (2024)
Aline Faucon, Julien Renault, Inokentijs Josts, Julie Couchot, Jean-Luc Renaud, Françoise Hoegy, Patrick Plésiat, Henning Tidow, Sylvain Gaillard, Gaëtan L A Mislin
Synthesis and antibacterial properties under blue LED light of conjugates between the siderophore desferrioxamine B (DFOB) and an Iridium(III) complex. Bioorganic & medicinal chemistry 112 (2024)

volume 111, 2024

Quanwei Yu, Chao Song, Liyun Bi, Shuang Zhao, Qian Lei, Na Yang, Hai Chen, Yuxi Wang, Yang He, Hui Deng
Design, synthesis and biological evaluation of naphthyl amide derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorganic & medicinal chemistry 111 (2024)
Hideaki Kageji, Takayuki Momose, Masayuki Ebisawa, Yusuke Nakazawa, Hiroyuki Okada, Noriko Togashi, Yasuhito Nagamoto, Wataru Obuchi, Isao Yasumatsu, Kawori Kihara, Kumiko Hiramoto, Megumi Minami, Naomi Kasanuki, Takeshi Isoyama, Hiroyuki Naito, Naoki Tanaka
Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity. Bioorganic & medicinal chemistry 111 (2024)
Xiubo Tang, Kai Hou, Xiaowu Chen, Wenyuan Fan, Hao Wu, Changliang Lu, Gong-Xin He
Discovery of macrocyclic covalent inhibitors for severe acute respiratory syndrome coronavirus 2 3CL protease. Bioorganic & medicinal chemistry 111 (2024)
Mieko Tsuji, Nobuyuki Koiso, Yufu Nishimura, Haruno Taira, Chinami Ogawa, Tasuku Hirayama, Hideko Nagasawa
Design and synthesis of visible light-activatable photocaged peroxides for optical control of ROS-mediated cellular signaling. Bioorganic & medicinal chemistry 111 (2024)
Jeffrey A Campbell, Phu Do, Zhiyu Li, Faisal Malik, Christopher Mead, Nick Miller, Christopher Pisiechko, Kimberly Powers, Zhijun Li
Synthesis and biological studies of 2-aminothiophene derivatives as positive allosteric modulators of glucagon-like peptide 1 receptor. Bioorganic & medicinal chemistry 111 (2024)
Heiya Na, Hui Luo, Jinlin Wang, Lijun Sun, Xin Gao, Guodong Liang, Yuheng Ma, Zhao Meng
An N-terminal heptad repeat trimer-based peptide fusion inhibitor exhibits potent anti-H1N1 activity. Bioorganic & medicinal chemistry 111 (2024)
Li Guan, Shengjie Zhang, Pengfei Song, Yanxin Xia, Xinle Zheng, Weize Li
Novel bibenzyl compound Ae exhibits anti-agiogenic activity in HUVECs in vitro and zebrafish in vivo. Bioorganic & medicinal chemistry 111 (2024)
Xiaomei Li, Hui Zhang, Sanfeng Dong, Xuejie Gao, Haiguo Sun, Zhaoyin Zhou, Ke Hu, Shushan Guo, Qikai Zhang, Zhufeng Guo, Samuel Jacob Bunu, Jianming Zhu, Bo Li, Yong Zhang, Jingshan Shen, Haji Akber Aisa, Zhijian Xu, Haiyan Cai, Jumei Shi, Weiliang Zhu
Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma. Bioorganic & medicinal chemistry 111 (2024)
João L P Ribeiro, Inês Costa, Renata Silva, Susana M M Lopes, Lucília Saraiva, Teresa M V D Pinho E Melo
3-Tetrazolyl-β-carboline derivatives as potential neuroprotective agents. Bioorganic & medicinal chemistry 111 (2024)
Zhengjia Zhao, Weikai Yan, Xiaocheng Weng
RNA modifications identification based on chemical reactions. Bioorganic & medicinal chemistry 111 (2024)
Yoshimasa Kawaguchi, Sakahiro Terada, Shiroh Futaki
An approach for the intracellular delivery of IgG via enzymatic ligation with a cell-permeable attenuated cationic amphiphilic lytic peptide. Bioorganic & medicinal chemistry 111 (2024)
Feng Zhang, Qimeng Yu, Caiyun Wu, Shishi Sun, Yu Wang, Rui Wang, Zejie Chen, Hua Zhang, Xuqiong Xiong, Annoor Awadasseid, Guowu Rao, Xiaoyin Zhao, Wen Zhang
Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction. Bioorganic & medicinal chemistry 111 (2024)
Théoneste Umumararungu, Jean Baptiste Nyandwi, Jonathan Katandula, Eric Twizeyimana, Jean Claude Tomani, Noël Gahamanyi, Nestor Ishimwe, Emmanuel Oladayo Olawode, Gratien Habarurema, Matabishi Mpenda, Jeanne Primitive Uyisenga, Shamsaldeen Ibrahim Saeed
Current status of the small molecule anti-HIV drugs in the pipeline or recently approved. Bioorganic & medicinal chemistry 111 (2024)
Kai-Yi Chen, You-Liang Zeng, Zong-Wan Mao, Wenting Liu
Development of a high quantum yield probe for detection of mitochondrial G-quadruplexes in live cells based on fluorescence lifetime imaging microscopy. Bioorganic & medicinal chemistry 111 (2024)
Ana Conejo-García, Yaiza Jiménez-Martínez, Rubén Cámara, Francisco Franco-Montalbán, Jesús Peña-Martín, Houria Boulaiz, M Dora Carrión
New substituted benzoxazine derivatives as potent inducers of membrane permeability and cell death. Bioorganic & medicinal chemistry 111 (2024)