Agostino Marrazzo

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Molecular Docking

Breast Cancer Cells

Neuropathic Pain

Top Venues

Molecules (Basel, Switzerland)

Journal of medicinal chemistry

ACS chemical neuroscience

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Lisa Lombardo, Salvatore Mirabile, Rosaria Gitto, Giuseppe Cosentino, Stefano Alcaro, Maria Dichiara, Agostino Marrazzo, Emanuele Amata, Francesco Ortuso, Laura De Luca
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches. Journal of chemical information and modeling 64 (14) (2024)
Nicole Ferrario, Emanuela Marras, Veronica Vivona, Federica Randisi, Antonino Nicolò Fallica, Agostino Marrazzo, Gianpaolo Perletti, Marzia Bruna Gariboldi
Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines. Cancers 16 (12) (2024)
Daniele Zampieri, Valentina Romano, Sara Fortuna, Emanuele Amata, Maria Dichiara, Giuseppe Cosentino, Agostino Marrazzo, Maria Grazia Mamolo
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors. Molecules (Basel, Switzerland) 29 (11) (2024)
Daniele Zampieri, Valentina Romano, Sara Fortuna, Emanuele Amata, Maria Dichiara, Giuseppe Cosentino, Agostino Marrazzo, Maria Grazia Mamolo
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors. Molecules (Basel, Switzerland) 29 (11) (2024)
Lisa Lombardo, Salvatore Mirabile, Rosaria Gitto, Giuseppe Cosentino, Stefano Alcaro, Maria Dichiara, Agostino Marrazzo, Emanuele Amata, Francesco Ortuso, Laura De Luca
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches. Journal of chemical information and modeling 64 (14) (2024)
Nicole Ferrario, Emanuela Marras, Veronica Vivona, Federica Randisi, Antonino Nicolò Fallica, Agostino Marrazzo, Gianpaolo Perletti, Marzia Bruna Gariboldi
Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines. Cancers 16 (12) (2024)
Lisa Lombardo, Salvatore Mirabile, Rosaria Gitto, Giuseppe Cosentino, Stefano Alcaro, Maria Dichiara, Agostino Marrazzo, Emanuele Amata, Francesco Ortuso, Laura De Luca
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches. Journal of chemical information and modeling (2024)
Maria Dichiara, Francesca Alessandra Ambrosio, Carla Barbaraci, Rafael González-Cano, Giosuè Costa, Carmela Parenti, Agostino Marrazzo, Lorella Pasquinucci, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS chemical neuroscience 14 (10) (2023)
Daniele Zampieri, Antonella Calabretti, Valentina Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands. Molecules (Basel, Switzerland) 28 (8) (2023)
Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska-Tłuścik, Bogusław Pilarski, Arkadiusz Leniak, Wojciech Pietruś, Sabina Podlewska, Katarzyna Popiołek-Barczyk, Laura J Humphrys, Ma Carmen Ruiz Cantero, David Reiner-Link, Luisa Leitzbach, Dorota Łażewska, Steffen Pockes, Michał Górka, Adam Zmysłowski, Thierry Calmels, Enrique J Cobos, Agostino Marrazzo, Holger Stark, Andrzej J Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz
Dual Piperidine-Based Histamine H 3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. Journal of medicinal chemistry (2023)
Maria Dichiara, Francesca Alessandra Ambrosio, Carla Barbaraci, Rafael González-Cano, Giosuè Costa, Carmela Parenti, Agostino Marrazzo, Lorella Pasquinucci, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS chemical neuroscience (2023)
Maria Dichiara, Francesca Alessandra Ambrosio, Carla Barbaraci, Rafael González-Cano, Giosuè Costa, Carmela Parenti, Agostino Marrazzo, Lorella Pasquinucci, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS chemical neuroscience 14 (10) (2023)
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
New Insights into the Opioid Analgesic Profile of cis -(-)- N -Normetazocine-derived Ligands. Molecules (Basel, Switzerland) 28 (12) (2023)
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
New Insights into the Opioid Analgesic Profile of cis -(-)- N -Normetazocine-derived Ligands. Molecules (Basel, Switzerland) 28 (12) (2023)
Maria Dichiara, Francesca Alessandra Ambrosio, Sang Min Lee, Ma Carmen Ruiz Cantero, Jessica Lombino, Adriana Coricello, Giosuè Costa, Dhara Shah, Giuliana Costanzo, Lorella Pasquinucci, Kyung No Son, Giuseppe Cosentino, Rafael González-Cano, Agostino Marrazzo, Vinay Kumar Aakalu, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity. Journal of medicinal chemistry (2023)
Maria Dichiara, Francesca Alessandra Ambrosio, Carla Barbaraci, Rafael González-Cano, Giosuè Costa, Carmela Parenti, Agostino Marrazzo, Lorella Pasquinucci, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS chemical neuroscience 14 (10) (2023)
Maria Dichiara, Francesca Alessandra Ambrosio, Carla Barbaraci, Rafael González-Cano, Giosuè Costa, Carmela Parenti, Agostino Marrazzo, Lorella Pasquinucci, Enrique J Cobos, Stefano Alcaro, Emanuele Amata
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS chemical neuroscience 14 (10) (2023)
Daniele Zampieri, Antonella Calabretti, Valentina Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands. Molecules (Basel, Switzerland) 28 (8) (2023)
Daniele Zampieri, Antonella Calabretti, Valentina Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands. Molecules (Basel, Switzerland) 28 (8) (2023)
Laura De Luca, Lisa Lombardo, Salvatore Mirabile, Agostino Marrazzo, Maria Dichiara, Giuseppe Cosentino, Emanuele Amata, Rosaria Gitto
Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity. RSC medicinal chemistry 14 (9) (2023)
Daniele Zampieri, Antonella Calabretti, Valentina Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands. Molecules (Basel, Switzerland) 28 (8) (2023)
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
New Insights into the Opioid Analgesic Profile of cis -(-)- N -Normetazocine-derived Ligands. Molecules (Basel, Switzerland) 28 (12) (2023)
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, Agostino Marrazzo, Giuseppe Romeo, Valeria Pittala, Khaled Greish, Luca Vanella, Giuseppe Floresta, Antonio Rescifina, Loredana Salerno, Sorrenti Valeria
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia. Molecules (Basel, Switzerland) 27 (10) (2022)
Antonino Nicolò Fallica, Carla Barbaraci, Emanuele Amata, Lorella Pasquinucci, Rita Turnaturi, Maria Dichiara, Sebastiano Intagliata, Marzia Bruna Gariboldi, Emanuela Marras, Viviana Teresa Orlandi, Claudia Ferroni, Cecilia Martini, Antonio Rescifina, Davide Gentile, Greta Varchi, Agostino Marrazzo
Correction to "Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents". Journal of medicinal chemistry 65 (16) (2022)
Nunzio Vicario, Simona Denaro, Rita Turnaturi, Lucia Longhitano, Federica Maria Spitale, Salvatore Spoto, Agostino Marrazzo, Agata Zappalà, Daniele Tibullo, Giovanni Li Volti, Santina Chiechio, Lorella Pasquinucci, Rosalba Parenti, Carmela Parenti
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain. International journal of molecular sciences 23 (11) (2022)
Rita Turnaturi, Santina Chiechio, Lorella Pasquinucci, Salvatore Spoto, Giuliana Costanzo, Maria Dichiara, Silvia Piana, Margherita Grasso, Emanuele Amata, Agostino Marrazzo, Carmela Parenti
Novel N -normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain. Molecules (Basel, Switzerland) 27 (16) (2022)
Antonino N Fallica, Valeria Pittala, Maria N Modica, Loredana Salerno, Giuseppe Romeo, Agostino Marrazzo, Mohamed A Helal, Sebastiano Intagliata
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective. Journal of medicinal chemistry 64 (12) (2021)
Katarzyna Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile, Vincenzo Patamia, Niklas Rosier, Denise Mönnich, Ma Carmen Ruiz Cantero, Tadeusz Karcz, Dorota Łażewska, Agata Siwek, Steffen Pockes, Enrique J Cobos, Agostino Marrazzo, Holger Stark, Antonio Rescifina, Andrzej J Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H 3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties. ACS chemical neuroscience 13 (1) (2021)
Carla Barbaraci, Giovanni Giurdanella, Claudia Giovanna Leotta, Anna Longo, Emanuele Amata, Maria Dichiara, Lorella Pasquinucci, Rita Turnaturi, Orazio Prezzavento, Ivana Cacciatore, Elisa Zuccarello, Gabriella Lupo, Giovanni Mario Pitari, Carmelina Daniela Anfuso, Agostino Marrazzo
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. Journal of medicinal chemistry 64 (18) (2021)
Antonino Nicolò Fallica, Carla Barbaraci, Emanuele Amata, Lorella Pasquinucci, Rita Turnaturi, Maria Dichiara, Sebastiano Intagliata, Marzia Bruna Gariboldi, Emanuela Marras, Viviana Teresa Orlandi, Claudia Ferroni, Cecilia Martini, Antonio Rescifina, Davide Gentile, Greta Varchi, Agostino Marrazzo
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. Journal of medicinal chemistry 64 (15) (2021)
Rita Turnaturi, Lorella Pasquinucci, Santina Chiechio, Margherita Grasso, Agostino Marrazzo, Emanuele Amata, Maria Dichiara, Orazio Prezzavento, Carmela Parenti
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist. ACS chemical neuroscience 11 (7) (2020)
Sebastiano Intagliata, Mohamed A Helal, Luisa Materia, Valeria Pittala, Loredana Salerno, Agostino Marrazzo, Alfredo Cagnotto, Mario Salmona, Maria N Modica, Giuseppe Romeo
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands. Molecules (Basel, Switzerland) 25 (8) (2020)
Valeria Ciaffaglione, Sebastiano Intagliata, Valeria Pittala, Agostino Marrazzo, Sorrenti Valeria, Luca Vanella, Antonio Rescifina, Giuseppe Floresta, Ameera Sultan, Khaled Greish, Loredana Salerno
New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells. International journal of molecular sciences 21 (6) (2020)
Maria Dichiara, Benedetto Amata, Rita Turnaturi, Agostino Marrazzo, Emanuele Amata
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis. ACS chemical neuroscience 11 (1) (2019)
Giuseppe Floresta, Maria Dichiara, Davide Gentile, Orazio Prezzavento, Agostino Marrazzo, Antonio Rescifina, Emanuele Amata
Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands. International journal of molecular sciences 20 (3) (2019)
Giuseppe Floresta, Venerando Pistarà, Kirsten E Christensen, Emanuele Amata, Agostino Marrazzo, Davide Gentile, Antonio Rescifina, Francesco Punzo
A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach. Molecules (Basel, Switzerland) 23 (12) (2018)
Giuseppe Floresta, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Loredana Salerno, Giuseppe Romeo, Orazio Prezzavento, Valeria Pittala, Antonio Rescifina
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis. ChemMedChem 13 (13) (2018)
Rita Turnaturi, Carmela Parenti, Orazio Prezzavento, Agostino Marrazzo, Paschalina Pallaki, Zafiroula Georgoussi, Emanuele Amata, Lorella Pasquinucci
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists. Molecules (Basel, Switzerland) 23 (3) (2018)
Khaled F Greish, Loredana Salerno, Reem Al Zahrani, Emanuele Amata, Maria N Modica, Giuseppe Romeo, Agostino Marrazzo, Orazio Prezzavento, Sorrenti Valeria, Antonio Rescifina, Giuseppe Floresta, Sebastiano Intagliata, Valeria Pittalà
Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation. Molecules (Basel, Switzerland) 23 (5) (2018)
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina
A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands. Marine drugs 16 (10) (2018)
Emanuele Amata, Maria Dichiara, Emanuela Arena, Valeria Pittalà, Venerando Pistarà, Venera Cardile, Adriana Carol Eleonora Graziano, Aurore Fraix, Agostino Marrazzo, Salvatore Sortino, Orazio Prezzavento
Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect. Journal of medicinal chemistry 60 (23) (2017)
Emanuele Amata, Antonio Rescifina, Orazio Prezzavento, Emanuela Arena, Maria Dichiara, Valeria Pittalà, Ángeles Montilla-García, Francesco Punzo, Pedro Merino, Enrique J Cobos, Agostino Marrazzo
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. Journal of medicinal chemistry 61 (1) (2017)