Aleem Gangjee

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 23

Top Topics

Molecular Docking

Structural Basis

Advanced Non Small Cell Lung Cancer

Induced Apoptosis

Top Venues

Molecular cancer therapeutics

ACS pharmacology & translational science

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer. Molecular cancer therapeutics (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Molecular cancer therapeutics 23 (6) (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Molecular cancer therapeutics 23 (6) (2024)
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Molecular cancer therapeutics 23 (6) (2024)
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Molecular cancer therapeutics 23 (6) (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer. Molecular cancer therapeutics (2024)
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N Fifer, Lily M Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H Matherly, Charles E Dann
Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Molecular cancer therapeutics 23 (6) (2024)
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer. Molecular cancer therapeutics (2024)
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C Nyman, Jade M Katinas, Mathew Schneider, Carrie O'Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H Matherly, Charles E Dann, Aleem Gangjee
Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. ACS pharmacology & translational science 6 (5) (2023)
Krishna Kaku, Manasa P Ravindra, Nian Tong, Shruti Choudhary, Xinxin Li, Jianming Yu, Mohammad Karim, Madelyn Brzezinski, Carrie O'Connor, Zhanjun Hou, Larry H Matherly, Aleem Gangjee
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport. ACS medicinal chemistry letters 14 (12) (2023)
Krishna Kaku, Manasa P Ravindra, Nian Tong, Shruti Choudhary, Xinxin Li, Jianming Yu, Mohammad Karim, Madelyn Brzezinski, Carrie O'Connor, Zhanjun Hou, Larry H Matherly, Aleem Gangjee
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport. ACS medicinal chemistry letters 14 (12) (2023)
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C Nyman, Jade M Katinas, Mathew Schneider, Carrie O'Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H Matherly, Charles E Dann, Aleem Gangjee
Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. ACS pharmacology & translational science 6 (5) (2023)
Md Junayed Nayeen, Jade M Katinas, Tejashree Magdum, Khushbu Shah, Jennifer E Wong, Carrie E O'Connor, Alexandra N Fifer, Adrianne Wallace-Povirk, Zhanjun Hou, Larry H Matherly, Charles E Dann, Aleem Gangjee
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. Journal of medicinal chemistry (2023)
Krishna Kaku, Manasa P Ravindra, Nian Tong, Shruti Choudhary, Xinxin Li, Jianming Yu, Mohammad Karim, Madelyn Brzezinski, Carrie O'Connor, Zhanjun Hou, Larry H Matherly, Aleem Gangjee
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport. ACS medicinal chemistry letters 14 (12) (2023)
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C Nyman, Jade M Katinas, Mathew Schneider, Carrie O'Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H Matherly, Charles E Dann, Aleem Gangjee
Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. ACS pharmacology & translational science 6 (5) (2023)
Manasa Ravindra, Adrianne Wallace-Povirk, Mohammad A Karim, Mike R Wilson, Carrie O'Connor, Kathryn White, Juiwanna Kushner, Lisa Polin, Christina George, Zhanjun Hou, Larry H Matherly, Aleem Gangjee
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of medicinal chemistry 61 (5) (2018)
Manasa Ravindra, Mike R Wilson, Nian Tong, Carrie O'Connor, Mohammad Karim, Lisa Polin, Adrianne Wallace-Povirk, Kathryn White, Juiwanna Kushner, Zhanjun Hou, Larry H Matherly, Aleem Gangjee
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. Journal of medicinal chemistry 61 (9) (2018)