Andrei Thomas-Tikhonenko

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 35

Top Venues

bioRxiv : the preprint server for biology

Nature communications

Cancer research

Leukemia

Children's Hospital of Philadelphia

Russian Cancer Research Center NN Blokhin (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Children's Hospital of Philadelphia Oct 01 2008

United States

Division Chief :: Cancer Pathobiology

University of Pennsylvania Sep 01 1997

United States

Professor :: Pathology & Laboratory Medicine

Fred Hutchinson Cancer Research Center Sep 01 1990 - Aug 31 1997

United States

Research Associate - Staff Scientist :: Division of Basic Sciences

Education History

Russian Cancer Research Center NN Blokhin Sep 01 1984 - Feb 18 1988

Russia

PHD :: Institute of Carcinogenesis

Moscow State University Sep 01 1979 - May 31 1984

Russia

BSC :: Biology

Publications

Manuel Torres-Diz, Clara Reglero, Catherine D Falkenstein, Annette Castro, Katharina E Hayer, Caleb M Radens, Mathieu Quesnel-Vallieres, Zhiwei Ang, Priyanka Sehgal, Marilyn M Li, Yoseph Barash, Sarah K Tasian, Adolfo A Ferrando, Andrei Thomas-Tikhonenko
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. Cancer research (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
The splicing modulator CLK1 is a candidate oncogenic dependency in pediatric high-grade gliomas. bioRxiv : the preprint server for biology (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
The splicing modulator CLK1 is a candidate oncogenic dependency in pediatric high-grade gliomas. bioRxiv : the preprint server for biology (2024)
Manuel Torres-Diz, Clara Reglero, Catherine D Falkenstein, Annette Castro, Katharina E Hayer, Caleb M Radens, Mathieu Quesnel-Vallieres, Zhiwei Ang, Priyanka Sehgal, Marilyn M Li, Yoseph Barash, Sarah K Tasian, Adolfo A Ferrando, Andrei Thomas-Tikhonenko
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. bioRxiv : the preprint server for biology (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv : the preprint server for biology (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv : the preprint server for biology (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv : the preprint server for biology (2024)
Manuel Torres-Diz, Clara Reglero, Catherine D Falkenstein, Annette Castro, Katharina E Hayer, Caleb M Radens, Mathieu Quesnel-Vallieres, Zhiwei Ang, Priyanka Sehgal, Marilyn M Li, Yoseph Barash, Sarah K Tasian, Adolfo A Ferrando, Andrei Thomas-Tikhonenko
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. bioRxiv : the preprint server for biology (2024)
Zhiwei Ang, Andrei Thomas-Tikhonenko
Lymphoma immunotherapy: the garden of forking paths. Blood 143 (8) (2024)
Ammar S Naqvi, Ryan J Corbett, Priyanka Seghal, Karina L Conkrite, Komal S Rathi, Brian M Ennis, Katharina E Hayer, Bo Zhang, Miguel A Brown, Daniel P Miller, Adam A Kraya, Joseph M Dybas, Zhuangzhuang Geng, Christopher Blackden, Shehbeel Arif, Antonia Chroni, Aditya Lahiri, Madison L Hollawell, Phillip B Storm, Jessica B Foster, Mateusz Koptyra, Peter J Madsen, Sharon J Diskin, Andrei Thomas-Tikhonenko, Adam C Resnick, Jo Lynne Rokita
Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv : the preprint server for biology (2024)
Zhiwei Ang, Andrei Thomas-Tikhonenko
Lymphoma immunotherapy: the garden of forking paths. Blood 143 (8) (2024)
Manuel Torres-Diz, Clara Reglero, Catherine D Falkenstein, Annette Castro, Katharina E Hayer, Caleb M Radens, Mathieu Quesnel-Vallieres, Zhiwei Ang, Priyanka Sehgal, Marilyn M Li, Yoseph Barash, Sarah K Tasian, Adolfo A Ferrando, Andrei Thomas-Tikhonenko
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. Cancer research (2024)
Manuel Torres-Diz, Clara Reglero, Catherine D Falkenstein, Annette Castro, Katharina E Hayer, Caleb M Radens, Mathieu Quesnel-Vallieres, Zhiwei Ang, Priyanka Sehgal, Marilyn M Li, Yoseph Barash, Sarah K Tasian, Adolfo A Ferrando, Andrei Thomas-Tikhonenko
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. Cancer research (2024)
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature communications 14 (1) (2023)
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature communications 14 (1) (2023)
Ning Li, Qin Zhu, Yuhua Tian, Kyung Jin Ahn, Xin Wang, Zvi Cramer, Justine Jou, Ian W Folkert, Pengfei Yu, Stephanie Adams-Tzivelekidis, Priyanka Sehgal, Najia N Mahmoud, Cary B Aarons, Robert E Roses, Andrei Thomas-Tikhonenko, Emma E Furth, Ben Z Stanger, Anil Rustgi, Malay Haldar, Bryson W Katona, Kai Tan, Christopher J Lengner
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment. Nature communications 14 (1) (2023)
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature communications 14 (1) (2023)
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature communications 14 (1) (2023)
Zhiwei Ang, Luca Paruzzo, Katharina E Hayer, Carolin Schmidt, Manuel Torres-Diz, Feng Xu, Urvi Zankharia, Yunlin Zhang, Samantha Soldan, Sisi Zheng, Catherine D Falkenstein, Joseph P Loftus, Scarlett Y Yang, Mukta Asnani, Patricia King Sainos, Vinodh Pillai, Emeline Chong, Marilyn M Li, Sarah K Tasian, Yoseph Barash, Paul M Lieberman, Marco Ruella, Stephen J Schuster, Andrei Thomas-Tikhonenko
Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. bioRxiv : the preprint server for biology (2023)
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature communications 14 (1) (2023)
Zhiwei Ang, Luca Paruzzo, Katharina E Hayer, Carolin Schmidt, Manuel Torres-Diz, Feng Xu, Urvi Zankharia, Yunlin Zhang, Samantha S Soldan, Sisi Zheng, Catherine D Falkenstein, Joseph Patrick Loftus, Scarlett Y Yang, Mukta Asnani, Patricia King Sainos, Vinodh Pillai, Emeline R Chong, Marilyn M Li, Sarah K Tasian, Yoseph Barash, Paul M Lieberman, Marco Ruella, Stephen J Schuster, Andrei Thomas-Tikhonenko
Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. Blood (2023)
Mathieu Quesnel-Vallieres, San Jewell, Kristen W Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
MAJIQlopedia: an encyclopedia of RNA splicing variations in human tissues and cancer. Nucleic acids research (2023)
Seong Woo Han, San Jewell, Andrei Thomas-Tikhonenko, Yoseph Barash
Contrasting and Combining Transcriptome Complexity Captured by Short and Long RNA Sequencing Reads. bioRxiv : the preprint server for biology (2023)
Asen Bagashev, Elena Sotillo, Chih-Hang Anthony Tang, Kathryn L Black, Jessica Perazzelli, Steven H Seeholzer, Yair Argon, David M Barrett, Stephan A Grupp, Chih-Chi Andrew Hu, Andrei Thomas-Tikhonenko
Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum". Molecular and cellular biology 42 (9) (2022)
Avery C Lee, Sai Ravi Pingali, Javier A Pinilla-Ibarz, Michael L Atchison, Constantinos Koumenis, Yair Argon, Andrei Thomas-Tikhonenko, Carl De Trez, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang
Loss of AID exacerbates the malignant progression of CLL. Leukemia 36 (10) (2022)
Scarlett Y Yang, Katharina E Hayer, Hossein Fazelinia, Lynn A Spruce, Mukta Asnani, Kathryn L Black, Ammar S Naqvi, Vinodh Pillai, Yoseph Barash, Kojo S J Elenitoba-Johnson, Andrei Thomas-Tikhonenko
FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells. Blood advances (2022)
Sisi Zheng, Elisabeth Gillespie, Ammar S Naqvi, Katharina E Hayer, Zhiwei Ang, Manuel Torres-Diz, Mathieu Quesnel-Vallières, David A Hottman, Asen Bagashev, John Chukinas, Carolin Schmidt, Mukta Asnani, Rawan Shraim, Deanne M Taylor, Susan R Rheingold, Maureen M O'Brien, Nathan Singh, Kristen W Lynch, Marco Ruella, Yoseph Barash, Sarah K Tasian, Andrei Thomas-Tikhonenko
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies. Blood cancer discovery 3 (2) (2022)
Adria Closa, Marina Reixachs-Solé, Antonio C Fuentes-Fayos, Katharina E Hayer, Juan L Melero, Fabienne R S Adriaanse, Romy S Bos, Manuel Torres-Diz, Stephen P Hunger, Kathryn G Roberts, Charles G Mullighan, Ronald W Stam, Andrei Thomas-Tikhonenko, Justo P. Castaño, Raúl M Luque, Eduardo Eyras
A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1. NAR cancer 4 (4) (2022)
Adria Closa, Marina Reixachs-Solé, Antonio C Fuentes-Fayos, Katharina E Hayer, Juan L Melero, Fabienne R S Adriaanse, Romy S Bos, Manuel Torres-Diz, Stephen P Hunger, Kathryn G Roberts, Charles G Mullighan, Ronald W Stam, Andrei Thomas-Tikhonenko, Justo P. Castaño, Raúl M Luque, Eduardo Eyras
A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1. NAR cancer 4 (4) (2022)
Claudia B Lanauze, Priyanka Sehgal, Katharina E Hayer, Manuel Torres-Diz, James A Pippin, Struan F A Grant, Andrei Thomas-Tikhonenko
Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding. Molecular cancer research : MCR 19 (5) (2021)
Priyanka Sehgal, Claudia Lanauze, Xin Wang, Katharina E Hayer, Manuel Torres-Diz, N Adrian Leu, Yogev Sela, Ben Z Stanger, Christopher J Lengner, Andrei Thomas-Tikhonenko
MYC Hyperactivates Wnt Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3. Molecular cancer research : MCR 19 (12) (2021)
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E Hayer, Mukta Asnani, Sarah K Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts. Genome biology 22 (1) (2021)
Colleen T Harrington, Elena Sotillo, Aude Robert, Katharina E Hayer, Agata M Bogusz, James Psathas, Duonan Yu, Deanne M Taylor, Chi V Dang, Peter S Klein, Michael D Hogarty, Birgit Geoerger, Wafik S El-Deiry, Joëlle Wiels, Andrei Thomas-Tikhonenko
Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma. Leukemia 33 (10) (2019)
Mukta Asnani, Katharina E Hayer, Ammar S Naqvi, Sisi Zheng, Scarlett Y Yang, Derek Oldridge, Fadia Ibrahim, Manolis Maragkakis, Matthew R Gazzara, Kathryn L Black, Asen Bagashev, Deanne M Taylor, Zissimos Mourelatos, Stephan A Grupp, David Barrett, John M Maris, Elena Sotillo, Yoseph Barash, Andrei Thomas-Tikhonenko
Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19. Leukemia 34 (4) (2019)
Asen Bagashev, Elena Sotillo, Chih-Hang Anthony Tang, Kathryn L Black, Jessica Perazzelli, Steven H Seeholzer, Yair Argon, David M Barrett, Stephan A Grupp, Chih-Chi Andrew Hu, Andrei Thomas-Tikhonenko
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum. Molecular and cellular biology 38 (21) (2018)

Andrei Thomas-Tikhonenko.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Andrei Thomas-Tikhonenko