Christian Heinis (C Heinis)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 37

Top Venues

Angewandte Chemie (International ed. in English)

Nature chemical biology

Nature communications

ACS chemical biology

EPFL

This page only lists publications with an associated author ORCID identifier.

Affiliation History

EPFL Sep 01 2008

Switzerland

Associate Professor :: Institute of Chemical Sciences and Engineering

Publications

Alexander L Nielsen, Zsolt Bognár, Ganesh Kumar Mothukuri, Anne Zarda, Mischa Schüttel, Manuel Leonardo Merz, Xinjian Ji, Edward J Will, Monica Chinellato, Christian R O Bartling, Kristian Stro Mgaard, Laura Cendron, Alessandro Angelini, Christian Heinis
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation. Angewandte Chemie (International ed. in English) 63 (26) (2024)
Alexander L Nielsen, Zsolt Bognár, Ganesh Kumar Mothukuri, Anne Zarda, Mischa Schüttel, Manuel Leonardo Merz, Xinjian Ji, Edward J Will, Monica Chinellato, Christian R O Bartling, Kristian Stro Mgaard, Laura Cendron, Alessandro Angelini, Christian Heinis
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation. Angewandte Chemie (International ed. in English) (2024)
Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L Nielsen, Christian Heinis
Solid-phase peptide synthesis in 384-well plates. Journal of peptide science : an official publication of the European Peptide Society 30 (4) (2024)
Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L Nielsen, Christian Heinis
Solid-phase peptide synthesis in 384-well plates. Journal of peptide science : an official publication of the European Peptide Society 30 (4) (2024)
Alexander L Nielsen, Zsolt Bognár, Ganesh Kumar Mothukuri, Anne Zarda, Mischa Schüttel, Manuel Leonardo Merz, Xinjian Ji, Edward J Will, Monica Chinellato, Christian R O Bartling, Kristian Stro Mgaard, Laura Cendron, Alessandro Angelini, Christian Heinis
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation. Angewandte Chemie (International ed. in English) 63 (26) (2024)
Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L Nielsen, Christian Heinis
Solid-phase peptide synthesis in 384-well plates. Journal of peptide science : an official publication of the European Peptide Society (2024)
Xinjian Ji, Alexander L Nielsen, Christian Heinis
Cyclic Peptides for Drug Development. Angewandte Chemie (International ed. in English) (2023)
Mischa Schüttel, Christian Heinis
High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides. Chembiochem : a European journal of chemical biology (2023)
Cristina Díaz-Perlas, Benjamin Ricken, Lluc Farrera-Soler, Dmitrii Guschin, Florence Pojer, Kelvin Lau, Christian-Benedikt Gerhold, Christian Heinis
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. Nature communications 14 (1) (2023)
Cristina Díaz-Perlas, Benjamin Ricken, Lluc Farrera-Soler, Dmitrii Guschin, Florence Pojer, Kelvin Lau, Christian-Benedikt Gerhold, Christian Heinis
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. Nature communications 14 (1) (2023)
Manuel Leonardo Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G L David, Alexander L Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M Duany Benitez, Phoukham Phothirath, Christian Heinis
De novo development of small cyclic peptides that are orally bioavailable. Nature chemical biology 20 (5) (2023)
Manuel Leonardo Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G L David, Alexander L Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M Duany Benitez, Phoukham Phothirath, Christian Heinis
De novo development of small cyclic peptides that are orally bioavailable. Nature chemical biology 20 (5) (2023)
Manuel Leonardo Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G L David, Alexander L Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M Duany Benitez, Phoukham Phothirath, Christian Heinis
De novo development of small cyclic peptides that are orally bioavailable. Nature chemical biology (2023)
Cristina Díaz-Perlas, Benjamin Ricken, Lluc Farrera-Soler, Dmitrii Guschin, Florence Pojer, Kelvin Lau, Christian-Benedikt Gerhold, Christian Heinis
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. Nature communications 14 (1) (2023)
Christian Heinis
Motifs for making tricycles. Nature chemical biology (2023)
Manuel Leonardo Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G L David, Alexander L Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M Duany Benitez, Phoukham Phothirath, Christian Heinis
De novo development of small cyclic peptides that are orally bioavailable. Nature chemical biology 20 (5) (2023)
Zsolt Bognár, Ganesh Kumar Mothukuri, Alexander L Nielsen, Manuel Leonardo Merz, Peter M F Pânzar, Christian Heinis
Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides. Organic & biomolecular chemistry 20 (29) (2022)
Patrick Gonschorek, Alessandro Zorzi, Tamara Maric, Mathilde Le Jeune, Mischa Schüttel, Mathilde Montagnon, Rebeca Gómez-Ojea, Denis Patrick Vollmar, Chantal Whitfield, Luc Reymond, Vanessa Carle, Hitesh Verma, Oliver Schilling, Alain Hovnanian, Christian Heinis
Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin. Journal of medicinal chemistry 65 (14) (2022)
Sevan Habeshian, Ganesh A Sable, Mischa Schüttel, Manuel L Merz, Christian Heinis
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase. ACS chemical biology 17 (1) (2022)
Sevan Habeshian, Manuel Leonardo Merz, Gontran Sangouard, Ganesh Kumar Mothukuri, Mischa Schüttel, Zsolt Bognár, Cristina Díaz-Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti, Laura Cendron, Alessandro Angelini, Christian Heinis
Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale. Nature communications 13 (1) (2022)
Christian Heinis
Combining biological and chemical diversity. Nature chemistry 13 (6) (2021)
Javier Ceballos, Elija Grinhagena, Gontran Sangouard, Christian Heinis, Jérôme Waser
Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents. Angewandte Chemie (International ed. in English) 60 (16) (2021)
Raphael J Gübeli, Davide Bertoldo, Kenji Shimada, Christian B Gerhold, Verena Hurst, Yuichiro Takahashi, Kai Harada, Ganesh Kumar Mothukuri, Jonas Wilbs, Masahiko Harata, Susan M Gasser, Christian Heinis
In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4. ACS chemical biology 16 (5) (2021)
Gontran Sangouard, Alessandro Zorzi, Yuteng Wu, Edouard Ehret, Mischa Schüttel, Sangram Kale, Cristina Díaz-Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti, Christian Heinis
Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer. Angewandte Chemie (International ed. in English) 60 (40) (2021)
Vanessa Carle, Yuteng Wu, Rakesh Mukherjee, Xu-Dong Kong, Chloé Rogg, Quentin Laurent, Enza Cecere, Camille Villequey, Madhuree S Konakalla, Tamara Maric, Christina Lamers, Cristina Díaz-Perlas, Kaycie Butler, Junko Goto, Bernd Stegmayr, Christian Heinis
Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation. Journal of medicinal chemistry 64 (10) (2021)
Xu-Dong Kong, Vanessa Carle, Cristina Díaz-Perlas, Kaycie Butler, Christian Heinis
Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product. ACS chemical biology 15 (11) (2020)
Debora Bertaggia Calderara, Maxime G Zermatten, Alessandro Aliotta, Ana Patricia Batista Mesquita Sauvage, Vanessa Carle, Christian Heinis, Lorenzo Alberio
Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy. Thrombosis and haemostasis 121 (2) (2020)
Ganesh Kumar Mothukuri, Sangram S Kale, Carl L Stenbratt, Alessandro Zorzi, Jonathan Vesin, Julien Bortoli Chapalay, Kaycie Deyle, Gerardo Turcatti, Laura Cendron, Alessandro Angelini, Christian Heinis
Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries. Chemical science 11 (30) (2020)
Jonas Wilbs, Xu-Dong Kong, Simon J Middendorp, Raja Prince, Alida Cooke, Caitlin T Demarest, Mai M Abdelhafez, Kalliope Roberts, Nao Umei, Patrick Gonschorek, Christina Lamers, Kaycie Deyle, Robert Rieben, Keith E Cook, Anne Angelillo-Scherrer, Christian Heinis
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs. Nature communications 11 (1) (2020)
Xu-Dong Kong, Jun Moriya, Vanessa Carle, Florence Pojer, Luciano Andrés Abriata, Kaycie Deyle, Christian Heinis
De novo development of proteolytically resistant therapeutic peptides for oral administration. Nature biomedical engineering 4 (5) (2020)
Khan Maola, Jonas Wilbs, Jeremy Touati, Michal Sabisz, Xu-Dong Kong, Alice Baumann, Kaycie Deyle, Christian Heinis
Engineered Peptide Macrocycles Can Inhibit Matrix Metalloproteinases with High Selectivity. Angewandte Chemie (International ed. in English) 58 (34) (2019)
Manh V Pham, Milan Bergeron-Brlek, Christian Heinis
Synthesis of DNA-Encoded Disulfide- and Thioether-Cyclized Peptides. Chembiochem : a European journal of chemical biology 21 (4) (2019)
Sangram Kale, Milan Bergeron-Brlek, Yuteng Wu, Ganesh Kumar Mothukuri, M V Pham, Julien Bortoli Chapalay, Jonathan Vesin, Xu-Dong Kong, João Franco Machado, Kaycie Butler, Patrick Gonschorek, Gerardo Turcatti, Laura Cendron, Alessandro Angelini, Christian Heinis
Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands. Science advances 5 (8) (2019)
Sangram S Kale, Camille Villequey, Xu-Dong Kong, Alessandro Zorzi, Kaycie Deyle, Christian Heinis
Cyclization of peptides with two chemical bridges affords large scaffold diversities. Nature chemistry 10 (7) (2018)
Simon J Middendorp, Jonas Wilbs, Claudia Quarroz, Sara Calzavarini, Anne Angelillo-Scherrer, Christian Heinis
Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity. Journal of medicinal chemistry 60 (3) (2017)
Kaycie Deyle, Xu-Dong Kong, Christian Heinis
Phage Selection of Cyclic Peptides for Application in Research and Drug Development. Accounts of chemical research 50 (8) (2017)
Jonas Wilbs, Simon J Middendorp, Christian Heinis
Improving the Binding Affinity of in-Vitro-Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone. Chembiochem : a European journal of chemical biology 17 (24) (2016)

Christian Heinis.css-eqlu8i{font-size:small;padding-left:4px;} (C Heinis)

Publication Activity (10 Years)

Top Topics

Top Venues

Christian Heinis (C Heinis)